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Comment
. 2022 Apr 12;55(4):586-588.
doi: 10.1016/j.immuni.2022.03.012.

Fungus packs a punch in the gut

Daniel H Cho  1 , Gloria B Choi  2
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Fungus packs a punch in the gut

Daniel H Cho et al. Immunity. .
Free article

Abstract

The impact of intestinal fungi on host physiology and their mechanisms of interaction are incompletely understood. In a recent issue of Cell, Leonardi et al. (2022) showed that mucosal fungi induce intestinal Th17 cells to produce IL-22 and IL-17A. IL-22 acts on the gut epithelium to protect barrier integrity, whereas IL-17 acts on IL-17RA+ neurons to enhance sociability.

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Declaration of interests The authors declare no competing interests.

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