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Review
. 2022 Apr 12;55(4):592-605.
doi: 10.1016/j.immuni.2022.03.016.

Nonresolving inflammation redux

Carl Nathan  1
Affiliations
Review

Nonresolving inflammation redux

Carl Nathan. Immunity. .

Abstract

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and long forms. Our understanding of inflammation is rapidly evolving. Like the immune system of which it is a part, inflammation can now be seen as an interactive component of a homeostatic network with the endocrine and nervous systems. This review samples emerging insights regarding inflammatory memory, inflammatory aging, inflammatory cell death, inflammatory DNA, inflammation-regulating cells and metabolites, approaches to resolving or modulating inflammation, and inflammatory inequity.

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Conflict of interest statement

Declaration of interests The author is a co-inventor on patents related to immunoproteasome inhibitors; a scientific co-founder and equity holder in IpiNovyx, Inc; a member of the National Therapeutic Areas scientific advisory board for Pfizer External Sciences & Innovation; and a member or the scientific advisory board of Leap Therapeutics.

Figures

Figure 1
Figure 1
Inflammation as a component of the homeostatic network The immune system (with inflammation as a prominent part), the endocrine system, and the nervous system interact with each other in a meta-system of homeostatic control and restoration. Each member of the tripartite system complements the others with respect to their range of action in space and time, the diversity and nature of responses they command, and their exertion of control at levels of cells, tissues, organs, and organism.
See this image and copyright information in PMC

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