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Review
. 2022 Mar 28:13:861878.
doi: 10.3389/fendo.2022.861878. eCollection 2022.

Challenges to Improve Bone Healing Under Diabetic Conditions

Yiling Chen  1 , Yue Zhou  1 , Jie Lin  2 , Shiwen Zhang  1   2
Affiliations
Review

Challenges to Improve Bone Healing Under Diabetic Conditions

Yiling Chen et al. Front Endocrinol (Lausanne). .

Abstract

Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinical significance in promoting fracture healing and improving bone integration. In this paper, we reviewed the methods of improving bone healing under diabetic conditions, including drug therapy, biochemical cues, hyperbaric oxygen, ultrasound, laser and pulsed electromagnetic fields, although most studies are in preclinical stages. Meanwhile, we also pointed out some shortcomings and challenges, hoping to provide a potential therapeutic strategy for accelerating bone healing in patients with diabetes.

Keywords: biomedical cues; bone healing; diabetic bone disease; diabetic drug; hyperglycemia; mesenchymal stem cells.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms of chronic hyperglycemia on bone healing. Chronic hyperglycemia can lead to oxidative stress, inflammatory reactions, adipogenesis/osteogenesis transformation imbalance, the production of AGEs, signaling pathway activation/inhibition, and bone microvascular changes, which can result in impaired bone healing.
Figure 2
Figure 2
Methods to improve bone healing in diabetic conditions.
See this image and copyright information in PMC

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