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Review
. 2022 Mar 28:13:845243.
doi: 10.3389/fimmu.2022.845243. eCollection 2022.

The Role of the Gut Microbiota in the Development of Ischemic Stroke

Jinchen Wang  1   2 , Hongfei Zhang  1 , Jianying He  3 , Xiaoxing Xiong  2
Affiliations
Review

The Role of the Gut Microbiota in the Development of Ischemic Stroke

Jinchen Wang et al. Front Immunol. .

Abstract

An increasing number of studies have focused on the gut microbiota and its relationship with various neurological diseases. The gut microbiota can affect the metabolic status of the body, in addition to having an important impact on blood pressure, blood glucose, and atherosclerosis, all of which are risk factors for ischemic stroke. In this review, we summarized studies that included the physiological function of the gut microbiota and gut microbiota disorders related to the central nervous system, thus providing novel ideas for the prevention and treatment of ischemic stroke.

Keywords: fecal microbiota transplantation; gut microbiota; gut-brain axis communication; ischemic stroke; neuro inflammation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
General concept of interactions between the gut microbiota and ischemic stroke. The brain and gut microbiota interact with each other through neural, endocrine, metabolic and immune pathways. A stroke can cause a series of reactions, such as gut microbiota disorder, microbial composition changes, and immune responses, while gut dysbiosis can lead to metabolic and immune response changes, systemic inflammation, and other reactions that result in increased neuroinflammation and poor stroke outcomes. Furthermore, hypertension, obesity, diabetes, and atherosclerosis are independent risk factors for stroke, and the gut microbiota may indirectly influence stroke by affecting these risk factors. Fecal microbiota transplantation, probiotics, butyrate, and tryptophane can improve the prognosis of stroke by improving the composition of the gut microbiota.
See this image and copyright information in PMC

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