Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Aug;45(4):2547-2564.
doi: 10.1007/s10143-022-01786-4. Epub 2022 Apr 14.

The prognostic significance of biomarkers in cerebrospinal fluid following severe traumatic brain injury: a systematic review and meta-analysis

Victor Schwartz Hvingelby  1   2 , Carsten Reidies Bjarkam  3 , Tiit Illimar Mathiesen  4   5 , Frantz Rom Poulsen  6   7 , Morten Thingemann Bøtker  8   9 , Andreas Husted  10 , Anders Rosendal Korshoej  8   11
Affiliations
Meta-Analysis

The prognostic significance of biomarkers in cerebrospinal fluid following severe traumatic brain injury: a systematic review and meta-analysis

Victor Schwartz Hvingelby et al. Neurosurg Rev. 2022 Aug.

Abstract

After severe traumatic brain injury (sTBI) proteins, neurotrophic factors and inflammatory markers are released into the biofluids. This review and meta-analysis searched the literature for prognostic candidate cerebrospinal fluid markers and their relation to sTBI patient outcome. A systematic search of the literature was carried out across PubMed, EMBASE, PubMed Central (PMC), and Cochrane Central Library. Biomarker concentrations were related to the Glasgow Outcome Scale dichotomized into favorable and unfavorable outcomes. When a biomarker was reported in ≥ 3 studies, it was included in meta-analysis. The search returned 1527 articles. After full-text analysis, 54 articles were included, 34 from the search, and 20 from the reference lists. Of 9 biomarkers, 8 were significantly different compared to controls (IL-4, IL-6, IL-8, IL-10, TNFα, sFas, BDNF, and cortisol). Of these, 5 were significantly increased in sTBI patients with unfavorable outcome (IL-6, IL-8, IL-10, TNFα, and cortisol), compared to patients with favorable outcome. This review demonstrated a correlation between 5 biomarkers and clinical outcome in sTBI patients. The paucity of included studies, however, makes it difficult to extrapolate further on this finding.

Keywords: Biomarker; Glasgow Outcome Score; Severe traumatic brain injury; Theranostics; Traumatic brain injury.

PubMed Disclaimer

References

    1. Murray CJL, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. The Lancet British edition 349:1498–1504. https://doi.org/10.1016/s0140-6736(96)07492-2 - DOI
    1. Eapen BC Cifu DX (2017) Traumatic brain injury rehabilitation. physical medicine and rehabilitation clinics of North America 28:i-i. doi: https://doi.org/10.1016/S1047-9651(17)30005-0
    1. Capizzi A, Woo J, Verduzco-Gutierrez M (2020) Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management. Med Clin North Am 104:213 - DOI
    1. Carney N, Totten AM, O’Reilly C, Ullman JS, Hawryluk GWJ, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, Rubiano AM, Shutter L, Tasker RC, Vavilala MS, Wilberger J, Wright DW, Ghajar J (2017) Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery 80:6–15. https://doi.org/10.1227/NEU.0000000000001432 - DOI - PubMed
    1. Chesnut RM, Ghajar J, Maas AIR, Marion DW, Servadei F, Teasdale G, Unterberg A, von Holst H, Walters BC (2000) Part 2: early indicators of prognosis in severe traumatic brain injury. J Neurotrauma 17:555–555. https://doi.org/10.1089/neu.2000.17.555 - DOI

LinkOut - more resources