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Review
. 2022 Jul;355(7):e2200052.
doi: 10.1002/ardp.202200052. Epub 2022 Apr 14.

Cinnamic acid hybrids as anticancer agents: A mini-review

Lian-Shun Feng  1 , Jin-Bo Cheng  1 , Wen-Qi Su  1 , Hong-Ze Li  2 , Tao Xiao  2 , De-An Chen  1 , Zhi-Liu Zhang  3
Affiliations
Review

Cinnamic acid hybrids as anticancer agents: A mini-review

Lian-Shun Feng et al. Arch Pharm (Weinheim). 2022 Jul.

Abstract

Cancer, as a long-lasting and dramatic disease, affects almost one-third of human beings globally. Chemotherapeutics play an important role in cancer treatment, but multidrug resistance and severe adverse effects have already become the main causes of failure in tumor chemotherapy. Therefore, it is an urgent need to develop novel chemotherapeutics. Cinnamic acid contains a ubiquitous α,β-unsaturated acid moiety presenting potential therapeutic effects in the treatment of cancer as these derivatives could act on cancer cells by diverse mechanisms of action. Accordingly, cinnamic acid derivatives are critical scaffolds in discovering novel anticancer agents. This review provides a comprehensive overview of cinnamic acid hybrids as anticancer agents. The structure-activity relationship, as well as the mechanisms of action, are also discussed, covering articles published from 2012 to 2021.

Keywords: anticancer; cinnamic acid; hybrids; mechanisms of action; structure-activity relationship.

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References

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