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. 2022 Jun;19(6):e202200207.
doi: 10.1002/cbdv.202200207. Epub 2022 May 3.

Two New Austocystin Analogs from the Marine-Derived Fungus Aspergillus sp. WHUF05236

Huawei Lv  1 , Jinkun Zhang  1 , Yaxin Xue  2 , Songwei Li  1 , Xiaoyu Sun  2 , Jia Jia  3 , Hongkai Bi  3 , Shoubao Wang  4 , Haibo Su  1 , Mengdi Zhu  5 , Hong Wang  1 , Kui Hong  2 , Xingnuo Li  1
Affiliations

Two New Austocystin Analogs from the Marine-Derived Fungus Aspergillus sp. WHUF05236

Huawei Lv et al. Chem Biodivers. 2022 Jun.

Abstract

Two new austocystin analogs, austocystin P (1) and austocystin Q (2), along with fourteen known compounds (3-16) were isolated from the fermentation extract of Aspergillus sp. WHUF05236. The planar structures of 1 and 2 were elucidated through 1D, 2D NMR and MS analyses. Their absolute configurations were determined by the time-dependent density functional (TDDFT)-ECD calculation. Compounds 3, 11, and 12 exhibited antimicrobial activities against Helicobacter pylori with MIC values ranging from 20.00 to 43.47 μM. Compounds 3, 6, and 7 showed cytotoxicities against the human colon cancer cell lines Hct-116 with IC50 values of 101.79, 65.46, and 36.72 μM, respectively.

Keywords: Aspergillus; antimicrobial activity; austocystin; marine-derived fungus; secondary metabolite.

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