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Editorial
. 2022 Apr 14;139(15):2265-2266.
doi: 10.1182/blood.2022015709.

TP53 and the star-crossed lovers MDS and AML

John S Welch  1
Affiliations
Editorial

TP53 and the star-crossed lovers MDS and AML

John S Welch. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: J.S.W. receives research support from Janssen Pharmaceuticals and Notable Labs.

Figures

None
AML and MDS represent related diagnoses of clonal myeloid disorders. Grob and colleagues report that in patients with AML or MDS with TP53 mutations clinical characteristics and outcomes are overlapping and propose that these 2 diseases be considered as a single diagnosis.
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Comment on

References

    1. Grob T, Al Hinai ASA, Sanders MA, et al. . Molecular characterization of mutant TP53 acute myeloid leukemia and high-hisk myelodysplastic syndrome. Blood. 2022;139(15):2347-2354. - PubMed
    1. Walter MJ, Shen D, Ding L, et al. . Clonal architecture of secondary acute myeloid leukemia. N Engl J Med. 2012;366(12):1090-1098. - PMC - PubMed
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    1. Lichtman MA. Does a diagnosis of myelogenous leukemia require 20% marrow myeloblasts, and does <5% marrow myeloblasts represent a remission? The history and ambiguity of arbitrary diagnostic boundaries in the understanding of myelodysplasia. Oncologist. 2013;18(9): 973-980. - PMC - PubMed
    1. Naqvi K, Jabbour E, Bueso-Ramos C, et al. . Implications of discrepancy in morphologic diagnosis of myelodysplastic syndrome between referral and tertiary care centers. Blood. 2011;118(17):4690-4693. - PMC - PubMed

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