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Comment
. 2022 Apr 15;376(6590):eabn8861.
doi: 10.1126/science.abn8861. Epub 2022 Apr 15.

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

Arturo Alvarez-Buylla  1   2 , Arantxa Cebrian-Silla  1   2 , Shawn F Sorrells  3 , Marcos Assis Nascimento  1   2 , Mercedes F Paredes  1   4 , Jose Manuel Garcia-Verdugo  5 , Zhengang Yang  6 , Eric J Huang  1   7
Affiliations
Comment

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

Arturo Alvarez-Buylla et al. Science. .

Abstract

Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin+ astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.

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References

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