Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Apr 15;376(6590):eabo0920.
doi: 10.1126/science.abo0920. Epub 2022 Apr 15.

Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

J Terreros-Roncal #  1   2   3 , E P Moreno-Jiménez #  1   2   3 , M Flor-García #  1   2   3 , C B Rodríguez-Moreno  1   3 , M F Trinchero  4 , B Márquez-Valadez  1   3 , F Cafini  5 , A Rábano  6 , M Llorens-Martín  1   3
Affiliations
Comment

Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

J Terreros-Roncal et al. Science. .

Abstract

Alvarez-Buylla and colleagues provide an alternative interpretation of some of the data included in our manuscript and question whether well-validated markers of adult hippocampal neurogenesis (AHN) are related to this phenomenon in our study. In Terreros-Roncal et al., reconstruction of the main stages of human AHN revealed its enhanced vulnerability to neurodegeneration. Here, we clarify ambiguities raised by these authors.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Vimentin and S100β staining in the human DG. ML: Molecular layer. GCL: Granule cell layer. SGZ: Subgranular zone. Yellow scale bar: 10 μm.
See this image and copyright information in PMC

Comment on

References

    1. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555:377–381. doi: 10.1038/nature25975. published online Epub Mar 15. - DOI - PMC - PubMed
    1. Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Farcía-Verdugo JM, Yang Z, Huang EJ. Impact of neurodegenerative diseases on human adulthippocampal neurogenesis. Science. 2022 Comment on XX, XX published online EpubXX (XXXX) - PMC - PubMed
    1. Terreros-Roncal J, Moreno-Jimenez EP, Flor-Garcia M, Rodriguez-Moreno CB, Trinchero MF, Cafini F, et al. Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science. 2021;374:1106–1113. doi: 10.1126/science.abl5163. published online Epub Nov 26. - DOI - PMC - PubMed
    1. Flor-Garcia M, Terreros-Roncal J, Moreno-Jimenez EP, Avila J, Rabano A, Llorens-Martin M. Unraveling human adult hippocampal neurogenesis. Nat Protoc. 2020;15:668–693. doi: 10.1038/s41596-019-0267-y. published online Epub Feb. - DOI - PubMed
    1. Moreno-Jimenez EP, Flor-Garcia M, Terreros-Roncal J, Rabano A, Cafini F, Pallas-Bazarra N, et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat Med. 2019;25:554–560. doi: 10.1038/s41591-019-0375-9. published online Epub Apr. - DOI - PubMed

Publication types