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Published Erratum
. 2022 Apr 14;59(4):2052559.
doi: 10.1183/13993003.52559-2020. Print 2022 Apr.

"Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis." Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, et al. Eur Respir J 2021; 57: 2002559

No authors listed
Published Erratum

"Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis." Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, et al. Eur Respir J 2021; 57: 2002559

No authors listed. Eur Respir J. .
No abstract available

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Figures

FIGURE 2
FIGURE 2
TD139 pharmacokinetics in healthy subjects and idiopathic pulmonary fibrosis (IPF) patients. ELF: epithelial lining fluid; AM: alveolar macrophage. a) Healthy subjects: log-linear mean plasma concentration of TD139 versus time over 48 h following a single dose of drug. b) IPF patients: log-linear mean plasma concentration of TD139 versus time over 24 h following the first dose of drug on day 1 or the last dose on day 14. c) Log-linear individual measured concentrations (median) in plasma (total), ELF and AMs at 2 h post-administration of 0.3, 3 and 10 mg TD139 on day 14. d) Correlation between concentrations of TD139 in ELF and AMs for all active cohorts on day 14 (r=0.87 (95% CI 0.56–0.96); p<0.001). e) Correlation between concentrations of TD139 in plasma (total) and AMs for all active cohorts on day 14 (r=0.89 (95% CI 0.65–0.96); p<0.0001). Shading represents 95% CI of the linear fit. For reference, the lower limit of detection in plasma was 0.5 ng·mL−1 and in BAL fluid was 5 ng·mL−1.
See this image and copyright information in PMC

Erratum for

  • Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
    Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM. Hirani N, et al. Eur Respir J. 2021 May 27;57(5):2002559. doi: 10.1183/13993003.02559-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33214209 Free PMC article. Clinical Trial.

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