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. 2021 Mar 22;11(19):11655-11662.
doi: 10.1039/d1ra00534k. eCollection 2021 Mar 16.

A novel one-pot synthesis of flavones

Meng-Yang Chang  1   2 , Min-Chen Tsai  1   2 , Chun-Yi Lin  1   2
Affiliations

A novel one-pot synthesis of flavones

Meng-Yang Chang et al. RSC Adv. .

Abstract

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecular ortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resulting o-hydroxychalcones. The reaction conditions are discussed herein.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Scheme 1
Scheme 1. Synthetic route of flavones.
Scheme 2
Scheme 2. Our synthetic route towards flavones.
Scheme 3
Scheme 3. Plausible mechanism.
Scheme 4
Scheme 4. Synthesis of 5a.
Scheme 5
Scheme 5. Synthesis of 6a and 7a.
See this image and copyright information in PMC

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