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. 1987 Jan 26;211(2):169-74.
doi: 10.1016/0014-5793(87)81430-8.

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

J J Holst, C Orskov, O V Nielsen, T W Schwartz
Free article

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

J J Holst et al. FEBS Lett. .
Free article

Abstract

By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

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