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Review
. 2022 Mar 29:12:867655.
doi: 10.3389/fonc.2022.867655. eCollection 2022.

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Vivek P Chavda  1 , Aayushi B Patel  2 , Kavya J Mistry  2 , Suresh F Suthar  2 , Zhuo-Xun Wu  3 , Zhe-Sheng Chen  3 , Kaijian Hou  4   5
Affiliations
Review

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

Vivek P Chavda et al. Front Oncol. .

Abstract

Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

Keywords: cancer; chemotherapy; drug delivery system; nanomedicine; natural bioactive compound; phytochemical.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Different cancer management procedures in Ayurveda.
Figure 2
Figure 2
Different nanotechnology-based carrier platforms for the efficient delivery of anticancer phytochemicals and different delivery mechanisms.
See this image and copyright information in PMC

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