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. 2022 Apr 5:2022:1280350.
doi: 10.1155/2022/1280350. eCollection 2022.

Toll-Like Receptors/TNF- α Pathway Crosstalk and Impact on Different Sites of Recurrent Myocardial Infarction in Elderly Patients

Xia Li  1 , Dianxuan Guo  1 , Ying Chen  1 , Youdong Hu  1
Affiliations

Toll-Like Receptors/TNF- α Pathway Crosstalk and Impact on Different Sites of Recurrent Myocardial Infarction in Elderly Patients

Xia Li et al. Biomed Res Int. .

Abstract

Background: Recurrent myocardial infarction is associated with increased mortality. Risk and predictive factors of recurrent myocardial infarction in elderly patients after coronary stenting are not well known. This research sought to investigate the effects of proinflammatory cytokines and toll-like receptor on recurrent myocardial infarction after coronary stenting in elderly patients.

Methods: We measured the levels of toll-like receptor 2 (TLR2), toll-like receptor 3 (TLR3), toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), soluble tumor necrosis factor-α receptor-1 (sTNFR-1), soluble tumor necrosis factor-α receptor-2 (sTNFR-2), endothelial progenitor cells (EPCs), and vascular endothelial growth factor (VEGF) in elderly patients with recurrent myocardial infarction and assessed the changes of proinflammatory cytokines and toll-like receptors in elderly patients with recurrent myocardial infarction after coronary stenting.

Results: Levels of TLR2, TLR3, TLR4, TNF-α, sTNFR-1, and sTNFR-2 were remarkably increased (P < 0.001), and EPCs and VEGF were remarkably lowered (P < 0.001) in the elderly patients with recurrent myocardial infarction after coronary stent implantation. Increased expressions of proinflammatory cytokines and toll-like receptors induced recurrent myocardial infarction after coronary stenting. Elevated expressions of proinflammatory cytokines and toll-like receptors may be used to identify elderly patients who have an increased risk of developing recurrent myocardial infarction after coronary stenting.

Conclusion: The increase levels of proinflammatory cytokines and toll-like receptors were associated with recurrent myocardial infarction after coronary stenting. Increased expressions of proinflammatory cytokines and toll-like receptors may be clinically useful biomarkers for predicting recurrent myocardial infarction in the elderly patients after coronary stent implantation.

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Conflict of interest statement

The authors declare that they have no competing interests regarding the publication of this article.

Figures

Figure 1
Figure 1
Flowchart of selection of eligible study subjects. RMI: recurrent myocardial infarction; RRVMI: recurrent right ventricular myocardial infarction; RLVMI: recurrent left ventricular myocardial infarction; RSTEMI: recurrent ST-elevation myocardial infarction; RNSTEMI: recurrent non-ST elevation myocardial infarction; RLMI: recurrent lateral myocardial infarction; RPMI: recurrent posterior myocardial infarction; RIMI: recurrent inferior myocardial infarction; RMMI: recurrent multiterritory myocardial infarction; RHLMI: recurrent high lateral myocardial infarction; RPLMI: recurrent postero-lateral myocardial infarction; RAMI: recurrent anterior myocardial infarction; REAMI: recurrent extensive anterior myocardial infarction.
See this image and copyright information in PMC

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