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. 2022 Apr 7;5(3):e586.
doi: 10.1002/hsr2.586. eCollection 2022 Apr.

Association of chronic inflammation with cardiovascular risk in chronic obstructive pulmonary disease-A cross-sectional study

Đivo Ljubičić  1   2 , Vedran Balta  3 , Dario Dilber  4 , Hrvoje Vražić  5 , Domagoj Đikić  3 , Dyana Odeh  3 , Jasna Čerkez Habek  6 , Emilija Lozo Vukovac  7 , Neven Tudorić  1   2
Affiliations

Association of chronic inflammation with cardiovascular risk in chronic obstructive pulmonary disease-A cross-sectional study

Đivo Ljubičić et al. Health Sci Rep. .

Abstract

Background and aims: COPD is progressive lung disease with known higher cardiovascular (CV) risk, mainly attributed to smoking of cigarettes as the main etiological factor of disease. The aim of this study was to compare CV risk in patients with COPD to control groups of smokers and non-COPD and to investigate the relation of lung function variables, COPD severity, and smoking with Systemic Coronary Risk Estimation (SCORE) risk calculation, arterial stiffness (AS) values, and biological systemic inflammatory markers.

Methods: A total of 208 subjects were included in this study: 61 subjects diagnosed with COPD, 83 smokers without COPD, and 64 nonsmokers without COPD. Medical history and clinical data were recorded, including assessment of pulmonary function and AS, calculation of ankle-brachial index, blood analysis, and CV risk assessment by SCORE risk calculation.

Results: Subjects with COPD had significantly higher values of SCORE calculation of risk, central aortic pressure, AS, and markers of systemic inflammation compared to control groups of smokers and nonsmokers without COPD (p < 0.001). Furthermore, statistically significant increase in hs-CRP concentration was found between the COPD group and the control group of non-COPD smokers (p < 0.001), and a statistically significantly higher SCORE calculation was found in the COPD group compared to control groups of smokers and nonsmokers without COPD (p < 0.001).

Conclusion: The results of the research support further identification and research of biological markers and simple specific tests such as arteriography that will enable progress in personalized treatment of patients with COPD and better primary and secondary prevention of comorbidities with the aim of improved treatment outcome.

Keywords: COPD; arterial stiffness; biological systems inflammatory markers; cardiovascular risk; lung function.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Regression line of significant correlation between PWVAо (m/s) and Systemic Coronary Risk Estimation (SCORE) risk calculation: Pearson's correlation coefficient, r = 0.390; p < 0.001
Figure 2
Figure 2
Regression line of significant correlation of obstruction by GOLD and Systemic Coronary Risk Estimation (SCORE) risk calculation: Pearson's correlation coefficient, r = 0.542; p < 0.001
Figure 3
Figure 3
Regression line of significant obstruction correlation by GOLD and PWVAо (m/s): Pearson's correlation coefficient, r = 0.496; p < 0.001
See this image and copyright information in PMC

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