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Review
. 2022 Jun 1;38(2):103-115.
doi: 10.1097/RUQ.0000000000000604.

Contrast-Enhanced Ultrasound as a Problem-Solving Modality: Tips and Tricks

Solomon Kim  1 , Komal Chughtai, Akshaar Brahmbhatt, Deborah Rubens, Vikram Dogra
Affiliations
Review

Contrast-Enhanced Ultrasound as a Problem-Solving Modality: Tips and Tricks

Solomon Kim et al. Ultrasound Q. .

Abstract

Contrast-enhanced ultrasound (CEUS) continues to be an ever-growing tool in radiation-free imaging. While it has been widely used in cardiac imaging, CEUS has only recently become an Food and Drug Administration-approved and viable modality for evaluation of abdominal structures. Ultrasound contrast agents are nontoxic, microbubble-based vascular agents and can be used to reliably assess enhancement patterns of various lesions in real time. In particular, it's non nephrotoxic nature makes CEUS a particularly important tool in renal failure patients requiring serial follow-up. This review provides a comprehensive discussion on the utility of CEUS agents, imaging techniques, comparison with traditional cross-sectional imaging modalities, and its application in diagnosing kidney and liver lesions. This pictorial review is illustrated with cases of renal and hepatic lesions that the practicing radiologist should become familiar with as CEUS becomes increasingly popular.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Furrer MA, Spycher SCJ, Büttiker SM, et al. Comparison of the diagnostic performance of contrast-enhanced ultrasound with that of contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging in the evaluation of renal masses: a systematic review and meta-analysis. Eur Urol Oncol . 2020;3(4):464–473.
    1. Chung YE, Kim KW. Contrast-enhanced ultrasonography: advance and current status in abdominal imaging. Ultrasonography . 2015;34(1):3–18.
    1. Cabassa P, Bipat S, Longaretti L, et al. Liver metastases: sulphur hexafluoride-enhanced ultrasonography for lesion detection: a systematic review. Ultrasound Med Biol . 2010;36(10):1561–1567.
    1. Cantisani V, Ricci P, Erturk M, et al. Detection of hepatic metastases from colorectal cancer: prospective evaluation of gray scale US versus SonoVue® low mechanical index real time-enhanced US as compared with multidetector-CT or Gd-BOPTA-MRI. Ultraschall Med . 2010;31(5):500–505.
    1. Medwin H. Counting bubbles acoustically: a review. Ultrasonics . 1977;15(1):7–13.