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. 2022 Aug 1;176(8):819-821.
doi: 10.1001/jamapediatrics.2022.1110.

Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2-A Report From the US National COVID Cohort Collaborative

Blake Martin  1 , Peter E DeWitt  2 , Seth Russell  2 , L Nelson Sanchez-Pinto  3 , Melissa A Haendel  4 , Richard Moffitt  5 , Tellen D Bennett  2
Affiliations

Acute Upper Airway Disease in Children With the Omicron (B.1.1.529) Variant of SARS-CoV-2-A Report From the US National COVID Cohort Collaborative

Blake Martin et al. JAMA Pediatr. .

Erratum in

  • Missing Funding Source.
    [No authors listed] [No authors listed] JAMA Pediatr. 2023 Jan 1;177(1):104. doi: 10.1001/jamapediatrics.2022.4601. JAMA Pediatr. 2023. PMID: 36342709 Free PMC article. No abstract available.
No abstract available

Plain language summary

This cohort study uses data from the US National COVID Cohort Collaborative to evaluate upper airway infections in children during the surge of the Omicron (B.1.1.529) variant of SARS-CoV-2 in the US.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Martin reports grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development during the conduct of the study and from Thrasher Research Fund Early Career Award outside the submitted work. Drs Sanchez-Pinto and Moffitt report grants from National Institutes of Health during the conduct of the study. Dr Bennett reports grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development during the conduct of the study and grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Heart, Lung, and Blood Institute, and the National Center for Advancing Translational Sciences outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. SARS-CoV-2–Positive Children With Upper Airway Infection (UAI)
The figure shows the percentage of pediatric SARS-CoV-2 cases per month among inpatient (solid line) and outpatient/emergency department (dotted line) encounters with a diagnosis of UAI within the National COVID Cohort Collaborative (N3C) February 17, 2022, data release. Per N3C policy, only data points in which the group (inpatient or outpatient and emergency department [ED]) had at least 20 patients are shown to prevent exposure of patient counts fewer than 20. Prior months are not shown given patient counts of fewer than 20 per month within the inpatient group before September 2021. Hospitalizations in February 2022 were fewer than 20 and are not shown. aThe percentage of sequenced SARS-CoV-2 samples found to be the Omicron strain among samples from weekly variant testing by the US Centers for Disease Control and Prevention COVID-19 Data Tracker increased from 0.6% during the week ending December 4, 2021, to 89.2% during the week ending January 1, 2022. bLinear regression identified the rate of change per month in SARS-CoV-2–positive children with a UAI diagnosis as 0.6% (standard error, 0.1%; P = .008) among hospitalized cases (solid line) and 0.2% (standard error, 0.03%; P = .005) among outpatient and emergency department cases (dotted line). Shaded regions indicate 95% CIs.
See this image and copyright information in PMC

References

    1. Martin B, DeWitt PE, Russell S, et al. . Characteristics, outcomes, and severity risk factors associated with SARS-CoV-2 infection among children in the US national COVID cohort collaborative. JAMA Netw Open. 2022;5(2):e2143151-e2143151. doi:10.1001/jamanetworkopen.2021.43151 - DOI - PMC - PubMed
    1. Venn AMR, Schmidt JM, Mullan PC. Pediatric croup with COVID-19. Am J Emerg Med. 2021;43:287.e281-287.e283. doi:10.1016/j.ajem.2020.09.034 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention . COVID Data Tracker: Variant Proportions. Accessed January 19, 2022. https://covid.cdc.gov/covid-data-tracker/#variant-proportions
    1. Chan MC, Hui KP, Ho J, et al. . SARS-CoV-2 Omicron variant replication in human respiratory tract ex vivo. Research Square. Preprint posted online December 22, 2021. doi:10.21203/rs.3.rs-1189219/v1 - DOI
    1. Haendel MA, Chute CG, Bennett TD, et al. ; N3C Consortium . The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment. J Am Med Inform Assoc. 2021;28(3):427-443. - PMC - PubMed

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