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Case Reports
. 2022 Jul;52(7):907-910.
doi: 10.1111/cea.14148. Epub 2022 Apr 22.

A novel gain-of-function mutation in STAT5B is associated with treatment-resistant severe atopic dermatitis

Nurhan Kasap  1 , Kubra Aslan  2 , Leman Tuba Karakurt  1 , Hayrunnisa Bozkurt  1 , Halit Canatan  2 , Ozlem Cavkaytar  1 , Ahmet Eken  2 , Mustafa Arga  1
Affiliations
Case Reports

A novel gain-of-function mutation in STAT5B is associated with treatment-resistant severe atopic dermatitis

Nurhan Kasap et al. Clin Exp Allergy. 2022 Jul.
No abstract available

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References

REFERENCES

    1. Hwa V. STAT5B deficiency: impacts on human growth and immunity. Growth Horm IGF Res. 2016;28:16-20. doi:10.1016/j.ghir.2015.12.006
    1. Bandapalli OR, Schuessele S, Kunz JB, et al. The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse. Haematologica. 2014;99(10):e188-e192. doi:10.3324/haematol.2014.104992
    1. Kucuk C, Jiang B, Hu X, et al. Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells. Nat Commun. 2015;6:6025. doi:10.1038/ncomms7025
    1. Cross NCP, Hoade Y, Tapper WJ, et al. Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia. Leukemia. 2019;33(2):415-425. doi:10.1038/s41375-018-0342-3
    1. Kawakami T, Ando T, Kawakami Y. Hypothetical atopic dermatitis-myeloproliferative neoplasm syndrome. Front Immunol. 2015;6:434. doi:10.3389/fimmu.2015.00434

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