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. 2022 May 4;13(9):1355-1357.
doi: 10.1021/acschemneuro.2c00195. Epub 2022 Apr 15.

Alzheimer's: The ABCDE Paradigm

Mayuri Gupta  1 , Donald F Weaver  1   2
Affiliations

Alzheimer's: The ABCDE Paradigm

Mayuri Gupta et al. ACS Chem Neurosci. .

Abstract

Alzheimer's disease (AD) and related dementias constitute a worldwide health crisis for which the design and development of global solutions is a neuropharmacologic priority. The much-publicized failures of multiple investigational agents for AD over the past 20 years drive the need to rethink our approach to therapeutics development. Herein we present the ABCDE paradigm as a conceptual tool to facilitate the development of safe, effective therapies for AD cure: (A) accessible; (B) blood-brain barrier permeant; (C) cognitive enhancing; (D) disease-modifying; (E) environmentally nontoxic.

Keywords: Alzheimer’s disease; biologics; blood−brain barrier; dementia; drug design; neurodegenerative disease; neuroinflammation; small-molecule therapeutics.

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