Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

P'ng Loke¹, Jian-Da Lin^{2

3}

Affiliations

¹ Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei City 10617, Taiwan.
³ Center for Computational and Systems Biology, National Taiwan University, Taipei City 10617, Taiwan.

Comment

P'ng Loke et al. Sci Immunol. 2022.

. 2022 Apr 15;7(70):eabo4652.

doi: 10.1126/sciimmunol.abo4652. Epub 2022 Apr 15.

P'ng Loke¹, Jian-Da Lin^{2

3}

¹ Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei City 10617, Taiwan.
³ Center for Computational and Systems Biology, National Taiwan University, Taipei City 10617, Taiwan.

Abstract

Single-cell transcriptomic data identifies major activation paths of monocyte-derived macrophages as a framework for inflammatory tissue macrophages.

A common framework of monocyte-derived macrophage activation.
Sanin DE, Ge Y, Marinkovic E, Kabat AM, Castoldi A, Caputa G, Grzes KM, Curtis JD, Thompson EA, Willenborg S, Dichtl S, Reinhardt S, Dahl A, Pearce EL, Eming SA, Gerbaulet A, Roers A, Murray PJ, Pearce EJ. Sanin DE, et al. Sci Immunol. 2022 Apr 15;7(70):eabl7482. doi: 10.1126/sciimmunol.abl7482. Epub 2022 Apr 15. Sci Immunol. 2022. PMID: 35427180 Free PMC article.