Trust your gut, lest thou be anxious
- PMID: 35427498
- DOI: 10.1016/j.cell.2022.03.035
Trust your gut, lest thou be anxious
Abstract
Can gut-residing bacteria influence mood and anxiety? And can targeting bacteria-produced metabolites reduce anxiety? Based on two Nature and Nature Medicine papers, the answers to these questions are likely yes. Needham, Campbell, and colleagues identified bacteria that enhance anxiety-like behaviors in mice and ways to mitigate anxiety in autistic patients.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests J.R.H. is a co-founder of Interon laboratories. He is also a consultant for CJ Biosience.
Comment on
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A gut-derived metabolite alters brain activity and anxiety behaviour in mice.Nature. 2022 Feb;602(7898):647-653. doi: 10.1038/s41586-022-04396-8. Epub 2022 Feb 14. Nature. 2022. PMID: 35165440 Free PMC article.
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Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.Nat Med. 2022 Mar;28(3):528-534. doi: 10.1038/s41591-022-01683-9. Epub 2022 Feb 14. Nat Med. 2022. PMID: 35165451 Clinical Trial.
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