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Case Reports
. 2022 Apr 15;15(4):e249039.
doi: 10.1136/bcr-2022-249039.

Dental management of a patient with systemic mastocytosis

Alexander Richard Legge  1 , Andrew Whyte  2 , Simon Heywood  3
Affiliations
Case Reports

Dental management of a patient with systemic mastocytosis

Alexander Richard Legge et al. BMJ Case Rep. .

Abstract

Mastocytosis is a term encompassing a group of clinical disorders characterised by clonal proliferation of abnormal mast cells (MCs) in organ systems of the body. Mastocytosis can be systemic (with or without skin involvement) or cutaneous, and can affect organs including bone marrow, liver, spleen, lymph nodes and mucosal surfaces. Patients with systemic mastocytosis (SM) are susceptible to triggers that could cause activation of abnormal MCs, resulting in multiorgan dysfunction and life-threatening anaphylactic reactions. Mastocytosis has a number of ramifications for the dental management of a patient with the condition. Patients are at increased risk of complications due to a number of risk factors for MC activation present within the dental context, including stress, certain prescribed drugs, oral hygiene products and dental materials. This report presents the oral management of an adult with SM, discussing the implications of the condition within the context of the limited existing literature on the subject.

Keywords: Dentistry and oral medicine; Immunology; Sedation; Surgery.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Periapical radiograph demonstrating suboptimal length and condensation of root treatment lower left first molar, with associated periapical radiolucencies.
Figure 2
Figure 2
Liver clots removed following postoperative haemorrhage.
See this image and copyright information in PMC

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