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. 2022 Jun;101(6):1282-1286.
doi: 10.1016/j.kint.2022.04.009. Epub 2022 Apr 13.

Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients

Ayman Al Jurdi  1 , Rodrigo B Gassen  2 , Thiago J Borges  2 , Isadora T Lape  2 , Leela Morena  2 , Orhan Efe  1 , Zhabiz Solhjou  3 , Rania El Fekih  3 , Christa Deban  3 , Brigid Bohan  4 , Vikram Pattanayak  5 , Camille N Kotton  6 , Jamil R Azzi  3 , Leonardo V Riella  7
Affiliations

Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients

Ayman Al Jurdi et al. Kidney Int. 2022 Jun.
No abstract available

Keywords: COVID-19; SARS-CoV-2; kidney transplant; vaccine.

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Figures

Figure 1
Figure 1
Increase in anti-spike antibody levels after the third dose of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in kidney transplant recipients (KTRs). (a,b) Total antibody (IgM, IgG, and IgA) mean fluorescence intensity (MFI) ratios to wild-type (WT) SARS-CoV-2 antigens before and after the third vaccine dose in KTRs (n = 51; a) and in prepandemic healthy controls (HCs; n = 5) and prepandemic kidney transplant control patients (KCs; n = 15), measured by Luminex-based multiplex assay (b). (c,d) Antibody MFI ratios for anti-spike antibodies of WT and variants of SARS-CoV-2 before and after the third vaccine dose in KTRs (c) and prepandemic HCs and KCs (d). Horizontal lines indicate positivity threshold for assay. (e,f) Proportion of KTRs with anti-spike antibodies against WT and variants of SARS-CoV-2 before (e) and after (f) the third vaccine dose. (a,c) Statistic by Wilcoxon matched-pairs signed rank test. (e,f) Statistic by χ2 test. NC, nucleocapsid; RBD, receptor-binding domain.
Figure 2
Figure 2
Poor anti–receptor binding domain (RBD) antibody and neutralization responses to the Omicron variant before and after the third dose of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in kidney transplant recipients (KTRs). (a,b) Anti–SARS-CoV-2 RBD IgG antibody OD 450 values to wild-type (WT), Delta (B.1.617.2), and Omicron (B.1.1.529) variants of SARS-CoV-2 before and after the third vaccine dose in KTRs (n = 51; a) and in prepandemic healthy controls (HCs; n = 5) and prepandemic kidney transplant control patients (KCs; n = 15), measured by enzyme-linked immunosorbent assay (b). (c,d) Percentage of neutralization to WT, Delta, and Omicron variants of SARS-CoV-2 before and after the third vaccine dose in KTRs (n = 51; c) and in prepandemic HCs (n = 5) and KCs (n = 15), measured by surrogate virus neutralization test (d). Horizontal lines indicate positivity threshold for assay. (e) Proportion of KTRs with a positive neutralization response before and after the third vaccine dose in KTRs. (a,c) Statistic by Friedman test with Dunn correction for multiple comparisons. (e) Statistic by χ2 test.
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References

    1. World Health Organization WHO coronavirus (COVID-19) dashboard. https://covid19.who.int/
    1. CDC: variant proportions. https://covid.cdc.gov/covid-data-tracker/#variant-proportions
    1. Caillard S., Chavarot N., Francois H., et al. Is COVID-19 infection more severe in kidney transplant recipients? Am J Transplant. 2021;21:1295–1303. - PMC - PubMed
    1. Boyarsky B.J., Werbel W.A., Avery R.K., et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325:2204–2206. - PMC - PubMed
    1. Benotmane I., Gautier-Vargas G., Cognard N., et al. Low immunization rates among kidney transplant recipients who received 2 doses of the mRNA-1273 SARS-CoV-2 vaccine. Kidney Int. 2021;99:1498–1500. - PMC - PubMed

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Supplementary concepts