Clinical Understanding of the Sleep-Immune Connection

Abstract

The science of sleep is becoming better understood all the time, and here is a fact that has only recently been revealed: sleep and immune system function have a bidirectional relationship. The disturbance of sleep can create an alteration in immune function. The opposite is also true, in that activation of the immune system can create a disturbance in sleep cycling. This dynamic can ultimately create a feed-forward loop of increasing immune dysfunction and sleep disruption. These systems are intimately intertwined. The clinical approach should be to intervene upstream in the regulation of the fundamental systems that control both sleep and immune function. Through the implementation of this approach, the treatment will focus on the cause of the epigenetic modulation of the sleep-immune system imbalance, and not just its effects and symptomatology.