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Review
. 2022 Mar 31:13:865303.
doi: 10.3389/fphar.2022.865303. eCollection 2022.

Related Markers for the Precision Diagnosis of Complex Appendicitis in Children

Jialin Zhou  1   2 , Wenjing Xu  3 , Jitao Wang  4 , Zhe Fan  1   2
Affiliations
Review

Related Markers for the Precision Diagnosis of Complex Appendicitis in Children

Jialin Zhou et al. Front Pharmacol. .

Abstract

Acute appendicitis is the most common surgical emergency in children. Despite the high incidence rate of appendicitis, it is sometimes misdiagnosed or missed. Complex appendicitis (CA) in children is characterized by a critical condition, several complications, and high mortality. Precision distinguishing between simple appendicitis and CA correctly is key to choosing appropriate treatment. A safe, cheap, rapid, extensive and accurate diagnostic marker of appendicitis will be of great significance for emergency general surgeons to treat suspected CA. Many studies have investigated possible diagnostic markers for the diagnosis of CA in children. In this study, studies related to CA in children in recent years are summarized, and the related markers and scoring system for the diagnosis of CA in children are summarized.

Keywords: biomarkers; children; complex appendicitis; rating related; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Markers for pediatric complex appendicitis.
See this image and copyright information in PMC

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References

    1. Adams R. A., Passino M., Sachs B. D., Nuriel T., Akassoglou K. (2004). Fibrin Mechanisms and Functions in Nervous System Pathology. Mol. Interv. 4 (3), 163–176. 10.1124/mi.4.3.6 - DOI - PubMed
    1. Arezes J., Jung G., Gabayan V., Valore E., Ruchala P., Gulig P. A., et al. (2015). Hepcidin-induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio Vulnificus. Cell Host Microbe 17 (1), 47–57. 10.1016/j.chom.2014.12.001 - DOI - PMC - PubMed
    1. Atema J. J., van Rossem C. C., Leeuwenburgh M. M., Stoker J., Boermeester M. A. (2015). Scoring System to Distinguish Uncomplicated from Complicated Acute Appendicitis. Br. J. Surg. 102 (8), 979–990. 10.1002/bjs.9835 - DOI - PubMed
    1. Augustin T., Cagir B., Vandermeer T. J. (2011). Characteristics of Perforated Appendicitis: Effect of Delay Is Confounded by Age and Gender. J. Gastrointest. Surg. 15 (7), 1223–1231. 10.1007/s11605-011-1486-x - DOI - PubMed
    1. Barreto S. G., Travers E., Thomas T., Mackillop C., Tiong L., Lorimer M., et al. (2010). Acute Perforated Appendicitis: an Analysis of Risk Factors to Guide Surgical Decision Making. Indian J. Med. Sci. 64 (2), 58–65. 10.4103/0019-5359.94401 - DOI - PubMed

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