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. 2021 Dec 1;14(1):9433.
doi: 10.4081/dr.2022.9433. eCollection 2022 Mar 11.

Nested melanoma

Davide Zardo  1 , Antonio Perasole  2 , Cesare Massone  3
Affiliations

Nested melanoma

Davide Zardo et al. Dermatol Reports. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Asymmetric, not sharply circumscribed, mostly junctional melanocytic proliferation (H&E; 20x).
Figure 2.
Figure 2.
Left half of the lesion: nests are different one from another, with different shape and dimension, asymmetric disposition and with uneven distribution of pigment (H&E; 40x).
Figure 3.
Figure 3.
Right half of the lesion: nests are different one from another, with different shape and dimension, asymmetric disposition and with uneven distribution of pigment (H&E; 40x).
Figure 4.
Figure 4.
The nests are expansile and push the epidermis from the bottom squeezing the stratum spinosum. The epidermis shows focal pigmented parakeratosis and pigmentation of basal keratinocytes (H&E; 100x).
Figure 5.
Figure 5.
At one edge of the lesion, atypical melanocytes in single unit are present in the stratum spinosum (H&E; 100x).
Figure 6.
Figure 6.
Irregular nests and single melanocytes in the epidermis also above the dermoepidermal junction. In the superficial dermis melanophages, few dendritic melanocytes and lymphocytes are present (H&E; 100x).
Figure 7.
Figure 7.
Irregular nests with cohesive melanocytes pushing the epidermis from the bottom (H&E; 200x).
Figure 8.
Figure 8.
Positivity BRAF-V600E and PRAME; heterogenous positivity for HMB-45 (x100).
See this image and copyright information in PMC

References

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