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Meta-Analysis
. 2022 Apr 8:2022:8448690.
doi: 10.1155/2022/8448690. eCollection 2022.

Effects of Misoprostol on Induction of Labour in Patients with Hypertensive Disorders of Pregnancy: A Meta-Analysis

Leilei Wang  1 , Sishi Liu  1 , Guiyu Song  1 , Man Gao  1 , Tong Liu  1
Affiliations
Meta-Analysis

Effects of Misoprostol on Induction of Labour in Patients with Hypertensive Disorders of Pregnancy: A Meta-Analysis

Leilei Wang et al. J Healthc Eng. .

Retraction in

Abstract

Objective: Hypertensive disorders of pregnancy (HDP) can cause serious prenatal and postnatal complications and is a threat to maternal and fetal health. To offer guidance for clinical decisions, we systematically reviewed the effects of misoprostol on induction of labour in HDP patients.

Methods: PubMed, Web of Science, Embase, CNKI, and Wanfang databases were searched for relevant literature from 2010 to 2020. Subsequently, a meta-analysis was performed to compare the effective rate of induction of labour and reducing postpartum hemorrhage (PPH) between the intervention group (n = 544, misoprostol) and the control group (n = 543, oxytocin).

Results: A total of 10 studies with 1087 patients were included. The 10 studies compared the effective rate of induction of labour between the two groups and confirmed that the effective rate in the intervention group was significantly higher than that in the control group (OR = 4.37; 95% CI: 2.73, 7.00). Seven studies compared PPH between the groups and showed that it was significantly reduced in the intervention group compared to the control group (SMD = -1.32; 95% CI: -2.05, -0.59; P < 0.0001).

Conclusion: Misoprostol has a high effective rate of induction of labour in HDP patients and is an effective uterotonic agent in reducing PPH. This meta-analysis provides clinicians with meaningful information to help them make evidence-based decisions.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Summary of literature retrieval process for effects of misoprostol on induction of labour in patients with hypertensive disorders of pregnancy.
Figure 2
Figure 2
Forest plot of induction of labour in the two groups.
Figure 3
Figure 3
Forest plot of amount of postpartum hemorrhage in the two groups.
Figure 4
Figure 4
Sensitivity analysis of the effective rate of induction of labour.
Figure 5
Figure 5
Sensitivity analysis of postpartum hemorrhage.
See this image and copyright information in PMC

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