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. 2022 Apr 12;10(4):e05645.
doi: 10.1002/ccr3.5645. eCollection 2022 Apr.

Disc-like lesions in the intestinal tract after renal transplantation

Arjan J Kwakernaak  1 , Rob W van der Pluijm  2 , Neelke C van der Weerd  3 , Lianne Koens  4 , Wytske M Westra  5 , Krisztina B Gecse  5 , Ankie Kleinjan  6
Affiliations

Disc-like lesions in the intestinal tract after renal transplantation

Arjan J Kwakernaak et al. Clin Case Rep. .

Abstract

We report a case of intestinal lesions in a patient with a history of lupus nephritis and renal transplantation. Biopsy revealed an EBV-driven post-transplant lymphoproliferative disease (PTLD). An EBV-driven PTLD is a major complication after renal transplantation and is an important differential diagnostic consideration in the follow-up of renal transplant recipients.

Keywords: EBV; PTLD; immunosuppression; lymphoma; renal transplantation.

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Conflict of interest statement

Not applicable.

Figures

FIGURE 1
FIGURE 1
Disc‐like lesions with central ulceration found with endoscopy
FIGURE 2
FIGURE 2
(A) HE section of the intestinal mucosa, showing large, atypical lymphocytes between the crypts. (B) The large lymphocytes show positivity for B‐cell marker CD20. (C) There is also extensive positivity in the EBER assay
See this image and copyright information in PMC

References

    1. Dierickx D, Habermann TM. Post‐transplantation lymphoproliferative disorders in adults. N Engl J Med. 2018;378:549‐562. - PubMed
    1. Al‐Mansour Z, Nelson BP, Evens AM. Post‐transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies. Curr Hematol Malig Rep. 2013;8:173‐183. - PMC - PubMed

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