Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 4:28:100298.
doi: 10.1016/j.jcte.2022.100298. eCollection 2022 Jun.

Clinical practice versus guidelines for the screening of cystic fibrosis-related diabetes: A French survey from the 47 centers

Laurence Weiss  1 , Olivia Ronsin  2 , Quitterie Reynaud  3 , Michel Abely  4 , Laurent Mely  5 , Pierre-Régis Burgel  6   7 , Jacques Beltrand  8   9 , Laurence Kessler  10   11
Affiliations

Clinical practice versus guidelines for the screening of cystic fibrosis-related diabetes: A French survey from the 47 centers

Laurence Weiss et al. J Clin Transl Endocrinol. .

Abstract

This study aimed to analyze clinical practices concerning cystic fibrosis-related diabetes (CFRD) screening in France. A web-based questionnaire was distributed between December 1, 2020 and January 31, 2021 among 47 cystic fibrosis centers including pediatric, adult, and mixed units. In accordance with guidelines, 92.8% of CF centers performed annual oral glucose tolerance tests (OGTT). Overall, 86.3% of CF centers performed 1- and 2-hour blood glucose determinations following OGTT. The OGTT was conducted before 10 years of age in 73% of pediatric centers. Continuous glucose monitoring (CGM) and laboratory glycated hemoglobin were employed for CFRD screening in 86.5% and 50% of centers, respectively. CGM was carried out in 69% of centers after glucose tolerance abnormalities had been detected in OGTT. Most CF centers used OGTT and CGM for CFRD screening. Studies are required to assess CGM usefulness as a validated tool in CFRD screening.

Keywords: Continuous glucose monitoring; Cystic fibrosis; Diabetes; OGTT; Screening.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Modalities of CFRD screenings in French cystic fibrosis centers (black column), pediatric centers (gray column), and adult centers (white column).
Fig. 2
Fig. 2
OGTT with and without T-1 h glucose (A) and targeted populations (B) in French cystic fibrosis centers (black column), pediatric centers (gray column), and adult centers (white column).
Fig. 3
Fig. 3
Role of CGM for CFRD screening according the OGTT (A) and the glucose values (B) of OGTT in French cystic fibrosis centers (black column), pediatric centers (gray column), and adult centers (white column).
See this image and copyright information in PMC

References

    1. Olesen H.V., Drenivek P., Gulmans V.A., Hatziagorou E., Jung A., Mei-Zahav M., et al. Cystic fibrosis related diabetes in Europe: prevalence, risk factors and outcome. J Cyst Fibros. 2020;19:321–327. - PubMed
    1. Milla C.E., Warwick W.J., Moran A. Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline. Am J Respir Crit Care Med. 2000;162(3):891–895. - PubMed
    1. Prentice B.J., Chelliah A., Ooi C.Y., Hameed S., Verge C.F., Plush L., et al. Peak OGTT glucose is associated with lower lung function in young children with cystic fibrosis. J Cyst Fibros. 2020;19(2):305–309. - PubMed
    1. Leclercq A., Gauthier B., Rosner V., Weiss L., Moreau F., Constantinescu A.A., et al. Early assessment of glucose abnormalities during continuous glucose monitoring associated with lung function impairment in cystic fibrosis patients. J Cyst Fibros. 2014;13(4):478–484. - PubMed
    1. Chan C.L. Continuous glucose monitoring in cystic fibrosis-benefits, limitations and opportunities. J Cyst Fibros. 2021;20(5):725–726. - PubMed

LinkOut - more resources