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Review
. 2022 Apr 1:10:867318.
doi: 10.3389/fchem.2022.867318. eCollection 2022.

Research Advances on Matrine

Xiao-Ying Sun  1 , Li-Yi Jia  1 , Zheng Rong  1 , Xin Zhou  2 , Lu-Qi Cao  2 , Ai-Hong Li  3 , Meng Guo  1 , Jie Jin  1 , Yin-Di Wang  1 , Ling Huang  1 , Yi-Heng Li  4 , Zhong-Jing He  4 , Long Li  2 , Rui-Kang Ma  2 , Yi-Fan Lv  2 , Ke-Ke Shao  2 , Juan Zhang  1 , Hui-Ling Cao  1   2   3   4
Affiliations
Review

Research Advances on Matrine

Xiao-Ying Sun et al. Front Chem. .

Abstract

Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors. The review introduced recent research progresses on extraction, synthesis and derivatization of Matrine. The summary focused on the latest research advances of Matrine on anti-atherosclerosis, anti-hypertension, anti-ischemia reperfusion injury, anti-arrhythmia, anti-diabetic cardiovascular complications, anti-tumor, anti-inflammatory, anti-bacterium, anti-virus, which would provide new core structures and new insights for new drug development in related fields.

Keywords: derivatization; extraction; matrine; molecular mechanism; pharmacological effects; synthesis.

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Conflict of interest statement

Authors A-HL and H-LC are employed by Shaanxi Pharmaceutical Holding Group Co., LTD, China. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Synthetic route of Matrine by Mandell et al. (1965).
FIGURE 2
FIGURE 2
Synthetic route of Matrine by Chen et al. (1986).
FIGURE 3
FIGURE 3
Synthetic route of Matrine by Fleming et al. (1997).
See this image and copyright information in PMC

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