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. 2022 Apr 1:9:851174.
doi: 10.3389/fmed.2022.851174. eCollection 2022.

Differential Effects of Intrauterine Balloon Tamponade Indications on Postpartum Hemorrhage Outcomes

Chuangchuang Xu  1   2   3 , Yiyao Chen  1   2   3 , Lin Wen  1   2   3 , Xiaolei Chi  1   2   3 , Xinliang Chen  1   2   3
Affiliations

Differential Effects of Intrauterine Balloon Tamponade Indications on Postpartum Hemorrhage Outcomes

Chuangchuang Xu et al. Front Med (Lausanne). .

Abstract

Objective: To determine whether the indication of intrauterine balloon tamponade (IUBT) was associated with postpartum hemorrhage (PPH) outcomes.

Methods: Patients with PPH who underwent IUBT between January 2013 and November 2021 were included in a cohort study. PPH outcomes in patients who had IUBT for indications of uterine atony were compared to those who had IUBT for indications of placental site bleeding. PPH outcomes included uterine artery embolization (UAE) or hysterectomy after IUBT, estimated blood loss (EBL) after balloon placement, and blood transfusion. Statistical analysis was performed using multivariate logistic regression.

Results: IUBT was performed on 603 cases, with 121 (20.1%) undergoing it for placental site bleeding and 482 (79.9%) for uterine atony. In general, IUBT was a reliable treatment for PPH, but the specific efficacy varied depending on the indication for placement. After controlling for confounding variables, compared to the indication of uterine atony, the indication of placental site bleeding increased the risk of transfusion of ≥4 units of PRBCs (aOR 2.47, 95%CI 1.32-3.98), EBL ≥ 300 ml after IUBT (aOR 3.78, 95%CI 2.22-5.33), and UAE or hysterectomy (aOR 2.52, 95%CI 1.20-6.01), respectively. Other factors associated with adverse PPH outcomes were lower antenatal hemoglobin, higher IUBT volume, longer duration of IUBT and larger shock index values.

Conclusions: IUBT was less effective in treating PPH patients with indications of placental site bleeding than with indications of uterine atony. Follow-up monitoring of PPH patients with placental site bleeding should be intensified.

Keywords: blood transfusion; estimated blood loss; hysterectomy; intrauterine balloon tamponade; placental site bleeding; postpartum hemorrhage; uterine artery embolization; uterine atony.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart. IUBT, intrauterine balloon tamponade; PPH, postpartum hemorrhage; UAE, uterine artery embolization.
See this image and copyright information in PMC

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