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. 2022 Mar 16;10(8):2393-2403.
doi: 10.12998/wjcc.v10.i8.2393.

Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

Wen Liu  1 , Bo Yin  2 , Zong-Hui Liang  3 , Yang Yu  2 , Na Lu  2
Affiliations

Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

Wen Liu et al. World J Clin Cases. .

Abstract

Background: Pancreatic adenocarcinoma is one of the most common malignant tumors of the digestive system. More than 80% of patients with pancreatic adenocarcinoma are not diagnosed until late stage and have distant or local metastases.

Aim: To investigate the value of computed tomography (CT) perfusion imaging in the evaluation of angiogenesis in pancreatic adenocarcinoma patients.

Methods: This is a retrospective cohort study. Patients with pancreatic adenocarcinoma and volunteers without pancreatic diseases underwent CT perfusion imaging from December 2014 to August 2017 in Huashan Hospital, Fudan University Shanghai, China.

Results: A total number of 35 pancreatic adenocarcinoma patients and 33 volunteers were enrolled. The relative blood flow (rBF), and relative blood volume (rBV) were significantly lower in patients with pancreatic adenocarcinoma than in the control group (P < 0.05). Conversely, the relative permeability in patients with pancreatic adenocarcinoma was significantly higher than that in controls (P < 0.05). In addition, rBF, rBV, and the vascular maturity index (VMI) were significantly lower in grade III-IV pancreatic adenocarcinoma than in grade I-II pancreatic adenocarcinoma (P < 0.05). Vascular endothelial growth factor (VEGF), CD105-MVD, CD34-MVD, and angiogenesis rate (AR) were significantly higher in grade III-IV pancreatic adenocarcinoma than in grade I-II pancreatic adenocarcinoma (P < 0.05). Significant correlations between rBF and VEGF, CD105-MVD, AR, and VMI (P < 0.01) were observed. Moreover, the levels of rBV were statistically significantly correlated with those of VEGF, CD105-MVD, CD34-MVD, and VMI (P < 0.01).

Conclusion: Perfusion CT imaging may be an appropriate approach for quantitative assessment of tumor angiogenesis in pancreatic adenocarcinoma.

Keywords: Angiogenesis; Evaluation; Imaging; Pancreatic adenocarcinoma; Perfusion computed tomography; Quantitative assessment.

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Conflict of interest statement

Conflict-of-interest statement: The authors have declared that they have no competing interests.

Figures

Figure 1
Figure 1
Representative computed tomography perfusion parameters in the pancreas of a healthy volunteer.
Figure 2
Figure 2
Representative computed tomography perfusion parameters of grade II (left) vs grade III (right) pancreatic adenocarcinoma patients.The pancreatic adenocarcinoma patients had a lower density on the maximum-density projection images, as well as lower values of blood flow, blood volume, and permeability, as compared with the adjacent relatively normal pancreatic tissue.
Figure 3
Figure 3
Immunohistochemical indicators in patients with pancreatic adenocarcinoma. CD34-MVD, CD105-MVD, VEGF, and (α-SMA)-MVD in patients with grade III pancreatic adenocarcinoma (right) were compared with CD34-MVD, CD105-MVD, VEGF, and (α-SMA)-MVD in patients with grade I pancreatic adenocarcinoma (left). Magnification × 400.
Figure 4
Figure 4
Correlation between relative blood flow and relative blood volume and angiogenesis rate. A: Correlation between relative blood flow and angiogenesis rate (AR); B: Correlation between relative blood volume and AR.
See this image and copyright information in PMC

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