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. 2022 Apr 18;17(4):e0267270.
doi: 10.1371/journal.pone.0267270. eCollection 2022.

Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort

Caroline Tianeze de Castro  1 , Marcos Pereira  2 , Djanilson Barbosa Dos Santos  1   3
Affiliations

Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort

Caroline Tianeze de Castro et al. PLoS One. .

Abstract

Background: Paracetamol is widely used to manage fever and pain during pregnancy worldwide. However, paracetamol may affect the pregnant woman and fetus, once this drug crosses the placental barrier after therapeutic doses and may impair fetal liver function, affecting fetus growth and development. Thus, this study aimed to investigate the association between paracetamol use during pregnancy and perinatal outcomes as preterm birth, low birth weight, and small for gestational age.

Methods and findings: Data from 760 pregnant women within the NISAMI Cohort between June 2012 and February 2014 were analyzed. Logistic regression was used to estimate the association among paracetamol use during pregnancy and preterm birth, low birth weight, and small for gestational age. Multivariate analyses were adjusted for socioeconomic, maternal, pregnancy, and newborn covariates. Around 14% of women were exposed to paracetamol during pregnancy. A decrease in paracetamol use throughout pregnancy was observed. Lower risk of low birth weight in infants born to women exposed to the drug (OR 0.21; IC 95% 0.01-0.99) was found. Paracetamol use during pregnancy was not statistically associated with preterm birth or small for gestational age.

Conclusions: The findings of this study do not suggest an increased risk of perinatal outcomes. However, it should not be assumed that paracetamol is a risk-free medication and its use must be rational.

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Conflict of interest statement

The authors declared that no competing interests exist.

Figures

Fig 1
Fig 1. Paracetamol use according to trimester of exposure and perinatal outcomes.
See this image and copyright information in PMC

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References

    1. Grzeskowiak LE, Gilbert AL, Morrison JL. Exposed or not exposed? Exploring exposure classification in studies using administrative data to investigate outcomes following medication use during pregnancy. Eur J Clin Pharmacol. 2012;68(5):459–67. doi: 10.1007/s00228-011-1154-9 - DOI - PubMed
    1. Adam MP, Polifka JE, Friedman JMM. Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet Part C Semin Med Genet. 2011;157(3):175–82. doi: 10.1002/ajmg.c.30313 - DOI - PubMed
    1. Daw JR, Hanley GE, Greyson DL, Morgan SG. Prescription drug use during pregnancy in developed countries: a systematic review. Pharmacoepidemiol Drug Saf. 2011. Jul;20(9):895–902. doi: 10.1002/pds.2184 - DOI - PMC - PubMed
    1. Sinclair SM, Miller RK, Chambers C, Cooper EM. Medication Safety During Pregnancy: Improving Evidence‐Based Practice. J Midwifery Womens Health. 2016;61(1):52–67. doi: 10.1111/jmwh.12358 - DOI - PubMed
    1. Allegaert K, van den Anker JN. Perinatal and neonatal use of paracetamol for pain relief. Semin Fetal Neonatal Med. 2017;22(5):308–13. doi: 10.1016/j.siny.2017.07.006 - DOI - PubMed

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