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. 1987 Jan;325(6101):223-8.
doi: 10.1038/325223a0.

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells

T E Adams, S Alpert, D Hanahan

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells

T E Adams et al. Nature. 1987 Jan.

Abstract

Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during beta cell development.

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