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. 2022 Jul;44(7):1725-1736.
doi: 10.1002/hed.27055. Epub 2022 Apr 18.

Systematic review of neuroendocrine carcinomas of the oropharynx

Michael H Froehlich  1 , Michael C Shih  1 , Lindsey Shehee  1 , Anvesh R Kompelli  1   2 , Alana Aylward  1 , Shaun A Nguyen  1 , John M Kaczmar  1 , Cherie Ann Nathan  2 , Terry Day  1 , David M Neskey  1
Affiliations

Systematic review of neuroendocrine carcinomas of the oropharynx

Michael H Froehlich et al. Head Neck. 2022 Jul.

Abstract

Data describing features and management of oropharyngeal neuroendocrine carcinomas (NEC) remain sparse. A systematic review was performed. Patients were stratified by treatment modality and examined for disease progression and survival outcomes. Ninety-four patients from 50 publications were included. Average age at diagnosis was 59.7 years (range 14-83). 73.4% were male. Most studies did not document HPV status. Forty patients (85.1%) were p16 positive, and 34 (85.0%) were HPV-ISH positive. Overall survival was 75.4% at 1 year, and 40.0% at 2 years. Of patients with locoregional disease, 33.8% developed distant metastasis. 12.5% of patients developed locoregional recurrence. Patients who developed distant metastases had worse overall survival (p = 0.0004). No significant difference was found between treatment modalities. Human papilloma virus may be associated with oropharyngeal NEC. Current treatments provide locoregional control, but distant metastases are common and confer low overall survival.

Keywords: chemotherapy; evidence-based medicine; neuroendocrine carcinoma; oropharynx; radiation therapy.

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References

REFERENCES

    1. Yao JC, Hassan M, Phan A, et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26(18):3063-3072.
    1. Subedi N, Prestwich R, Chowdhury F, Patel C, Scarsbrook A. Neuroendocrine tumours of the head and neck: anatomical, functional and molecular imaging and contemporary management. Cancer Imaging. 2013;13(3):407-422.
    1. van der Laan TP, Plaat BE, van der Laan BF, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases. Head Neck. 2015;37(5):707-715.
    1. Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer. 1997;79(9):1729-1736.
    1. Jo VY, Krane JF, Pantanowitz L, Monaco SE. HPV-associated neuroendocrine carcinomas of the head and neck in FNA biopsies: clinicopathologic features of a rare entity. Cancer Cytopathol. 2019;127(1):26-34.

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