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Review
. 2022 Apr;17(9):645-664.
doi: 10.2217/nnm-2021-0473. Epub 2022 Apr 19.

Ligand-mediated nanomedicines against breast cancer: a review

Guilherme F Picheth  1   2 , Fernando A de O Ganzella  1 , João Oc Filizzola  1 , Yan K Canquerino  1 , Gabriela C Cardoso  1 , Michelle B Collini  1 , Leonardo B Colauto  1 , Maria Cristina Figueroa-Magalhães  2 , Edneia Asr Cavalieri  1 , Giseli Klassen  1
Affiliations
Review

Ligand-mediated nanomedicines against breast cancer: a review

Guilherme F Picheth et al. Nanomedicine (Lond). 2022 Apr.

Abstract

Ligand-mediated targeting represents the cutting edge in precision-guided therapy for several diseases. Surface engineering of nanomedicines with ligands exhibiting selective or tailored affinity for overexpressed biomolecules of a specific disease may increase therapeutic efficiency and reduce side effects and recurrence. This review focuses on newly developed approaches and strategies to improve treatment and overcome the mechanisms associated with breast cancer resistance.

Keywords: HER2; TNBC; active targeting; luminal; nanoparticle; receptor-targeted.

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