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Observational Study
. 2022 Jul;27(7):566-576.
doi: 10.1111/nep.14045. Epub 2022 May 7.

COVID-19 death and kidney disease in a multiracial Asian country

Bak Leong Goh  1   2 , Malini Shanmuganathan  1 , Kalaiarasu Peariasamy  3 , Nor Arisah Misnan  4 , Suresh Kumar Chidambaram  4 , Eddie Fook Sem Wong  5 , Mohan Dass Pathmanathan  3 , Kim Liong Ang  1 , Hin Seng Wong  6 , Lena Lay Ling Yeap  7
Affiliations
Observational Study

COVID-19 death and kidney disease in a multiracial Asian country

Bak Leong Goh et al. Nephrology (Carlton). 2022 Jul.

Abstract

Introduction: COVID-19 infection and kidney disease (KD) carry a considerable risk of mortality. Understanding predictors of death and KD may help improve management and patient outcome.

Methods: This is a prospective multicentre observational study conducted in a multiracial Asian country to identify predictors of death and acute kidney injury (AKI) in hospitalized COVID-19 patients from January to June 2020.

Results: A total of 6078 patients were included in this study. Mean age was 37.3 (±16.8) years, 71% were male, 59.4% Malay, 6.7% Chinese, 2.3% Indian and 31.7% other ethnicities. AKI was seen in 3.5% of patients while 1.6% had pre-existing chronic kidney disease (CKD). Overall case fatality rate (CFR) was 1.3%. Patients with KD (AKI and CKD) had CFR of 20%. Many factors were associated with increased risk of death and AKI. However, significant predictors of death after adjustment for covariates were age (>70 years), Chinese ethnicity, diabetes mellitus (DM) and KD. Adjusted predictors of AKI were age (>51 years), DM and severity at presentation. Chinese were 2.58 times more likely to die (p = .036) compared to Malay. Centre capacity to manage, ventilate and dialyze patients significantly influenced death. Among those with AKI, the most common symptoms were fever, cough, and dyspnea. They had lower absolute lymphocyte count, were more likely to be admitted to ICU, required more ventilation and longer hospitalization.

Conclusion: Patient and centre factors influence death and AKI among COVID-19 patients. This study also demonstrates death disparities across different racial groups and centre capacities in this multiracial Asian country.

Keywords: COVID-19; death; ethnicity; kidney disease; risk factors.

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References

    1. World Health Organisation . https://covid19.who.int/. 2021.
    1. Abuelgasim E, Saw LJ, Shirke M, Zeinah M, Harky A. COVID‐19: unique public health issues facing black, Asian and minority ethnic communities. Curr Probl Cardiol. 2020;45(8):100621. - PMC - PubMed
    1. Henning‐Smith C, Tuttle M, Kozhimannil KB. Unequal distribution of COVID‐19 risk among rural residents by race and ethnicity. J Rural Health. 2021;37(1):224‐226. - PMC - PubMed
    1. Centers for Disease Control and Prevention, USA . Risk for COVID‐19 Infection, Hospitalization, and Death by Race/Ethnicity. https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-disc....
    1. Ministry of Health Malaysia. Clinical Management of Confirmed COVID‐19 Case in Adult and Paediatric. www.covid-19.moh.gov.my/garis-panduan/garis-panduan-kkm

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