Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 20;43(3):357-361.
doi: 10.1515/hmbci-2021-0044. eCollection 2022 Sep 1.

A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome

Ashok Kumar Shah  1 , Birendra Kumar Yadav  2 , Arpita Suri  3 , Amrendra Kumar Shah  4
Affiliations

A study on lipoprotein-a and PAI-1 in women with polycystic ovary syndrome

Ashok Kumar Shah et al. Horm Mol Biol Clin Investig. .

Abstract

Objectives: PCOS is the most common endocrinological disorder amongst women of reproductive age. The consequences of PCOS extend beyond the reproductive axis and may lead to the development of metabolic syndrome leading to a high risk for hypertension and cardiovascular disease. Therefore, a more comprehensive evaluation of biochemical markers that reflect the cardiovascular risk is required for further understanding of pathophysiologic mechanisms, diagnosis and management.

Methods: In this case-control study, women diagnosed with PCOS (n=100) in the age group (18-35 years) years were taken as cases and age matched healthy controls (n=100) were enrolled. Estimations of fasting plasma Glucose, serum total cholesterol (TC), triglycerides (TG) and High-density lipoprotein (HDL) concentrations were assayed while Low-density lipoprotein (LDL) was calculated by using Fredrickson Friedwald's formula. Serum Lipoprotein-a (Lp-a) was estimated using ELISA (Enzyme Linked Immunosorbent Assay). The quantitative data were expressed as Mean ± Standard Deviation (SD). Unpaired Student's t-test was used to compare the values (PCOS vs Controls) and Pearson's correlation coefficient was used to elucidate the relationship between the variables.

Results: FBS and all lipid parameters were significantly increased in PCOS patients compared to control subjects. On the other hand, HDL-C was significantly decreased as compared to the control subjects. The hormones TSH, LH, FSH, PRL and LH/FSH ratio were significantly increased in PCOS patients compared to control subjects. Lipoprotein-a and PAI-1 was significantly increased in PCOS patients compared to the control subjects. Upon bivariate correlation analysis, Lp(a) had significant correlations with PAI-1 (r=0.35, p=0.000), WHR (r=0.25, p=0.000), LDL (r=0.52, p=0.000) and TSH (r=0.24, p=0.000). While the correlations with FBS (r=-0.008, p=0.91) and LH/FSH ratio (r=-0.004, p=0.95) were statistically insignificant.

Conclusions: The evaluation of serum biomarkers such as Lp-a, PAI-1 and lipid profile routinely in PCOS patients may have diagnostic role in the early detection of metabolic abnormalities and endocrine derangements and timely management of comorbid Diabetes and Cardiovascular disease in PCOS females.

Keywords: PAI-1; PCOS; cardiovascular risk; dyslipidemia; lipoprotein-a.

PubMed Disclaimer

References

    1. Hoffman, BL, Schorge, JO, Halvorson, LM, Bradshaw, KD, Cunningham, FG. Polycystic ovarian syndrome and hyperandrogenism: Williams gynecology, 2nd ed New York City, USA: McGraw Hill Medical; 2012:460 p.
    1. Gazvani, MR, Hamilton, M, Kingsland, CR, Templeton, A. Polycystic ovarian disease: a misleading label? Lancet 2000;355:411–2.
    1. Ferriman, D, Gallwey, JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440–7.
    1. Vgontzas, AN, Legro, RS, Bixler, EO, Grayev, A, Kales, A, Chrousos, GP. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 2001;86:517–20.
    1. Fogel, RB, Malhotra, A, Pillar, G, Pittman, SD, Dunaif, A, White, DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:1175–80.

LinkOut - more resources