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. 2022 Apr;79(3-4):133-140.
doi: 10.1024/0040-5930/a001339.

[Achalasia Update]

[Article in German]
Ulrich Klaus Fetzner  1   2 , Martha Trujillo  3 , Ioannis Dimopoulos  1 , Marc Frederic Hoffmann  4 , Felix Berlth  2 , Carolina Mann  2 , Peter Grimminger  2 , Berthold Gerdes  1
Affiliations

[Achalasia Update]

[Article in German]
Ulrich Klaus Fetzner et al. Ther Umsch. 2022 Apr.

Abstract
in English, German

Achalasia Update Abstract. The neurodegenerative disease achalasia (obsolete: "cardiac spasm") is the second most common functional disease of the esophagus after reflux disease. It is associated with an extremely high level of suffering for the patient. Pathophysiologically, it is a combination of a lack of swallowing-reflex relaxation at the gastric entrance and disturbed peristalsis of the tubular esophagus. The gold standard in diagnostics is high-resolution manometry. The disease cannot be cured, the therapeutic spectrum that alleviates the disease includes pharmaceutical, endoscopic-interventional and surgical procedures.

Zusammenfassung. Die neurodegenerative Erkrankung Achalasie (veraltet: «Kardiaspasmus») stellt nach der Refluxerkrankung die zweithäufigste funktionelle Erkrankung des Ösophagus dar. Sie ist mit einem extrem hohen Leidensdruck für die Patienten verbunden. Pathophysiologisch handelt es sich um eine Kombination aus fehlender schluckreflektorischer Relaxation am Mageneingang und gestörter Peristaltik der tubulären Speiseröhre. Goldstandard in der Diagnostik ist die hochauflösende Manometrie. Die Erkrankung ist nicht heilbar, das therapeutisch Spektrum umfasst medikamentöse, endoskopisch-interventionelle und operative Verfahren.

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