Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition

Bob T Li^#¹, Bobby Daly^#², Mary Gospodarowicz³, Monica M Bertagnolli⁴, Otis W Brawley⁵, Bruce A Chabner^{6

7}, Lola Fashoyin-Aje⁸, R Angelo de Claro⁸, Elizabeth Franklin⁹, Jennifer Mills¹⁰, Jeff Legos¹¹, Karen Kaucic¹², Mark Li¹³, Lydia The¹⁴, Tina Hou¹⁴, Ting-Hui Wu¹⁴, Bjorn Albrecht¹⁴, Yi Shao¹⁴, Justin Finnegan¹⁵, Jing Qian¹⁶, Javad Shahidi¹⁷, Eduard Gasal¹⁸, Craig Tendler¹⁹, Geoffrey Kim²⁰, James Yan²¹, Phuong Khanh Morrow²², Charles S Fuchs^{23

24}, Lianshan Zhang²⁵, Robert LaCaze²⁶, Stefan Oelrich²⁶, Martin J Murphy^{7

27

28}, Richard Pazdur⁸, Kevin Rudd¹⁶, Yi-Long Wu²⁹

Affiliations

¹ Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY, USA. lib1@mskcc.org.
² Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY, USA.
³ Princess Margaret Cancer Center, , University of Toronto, Toronto, Ontario, Canada.
⁴ Dana-Farber Brigham Cancer Center, Harvard Medical School, Boston, MA, USA.
⁵ Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁶ Massachusetts General Hospital Cancer Center, Boston, MA, USA.
⁷ Society for Translational Oncology, Durham, NC, USA.
⁸ Oncology Center of Excellence, Food and Drug Administration, Silver Spring, MD, USA.
⁹ Cancer Support Community, Washington, DC, USA.
¹⁰ Foundation Medicine, Inc., Cambridge, MA, USA.
¹¹ Novartis, Basel, Switzerland.
¹² PPD, Inc., Wilmington, NC, USA.
¹³ Resolution Bioscience, Agilent Technologies, Kirkland, WA, USA.
¹⁴ McKinsey Cancer Center, McKinsey & Company.
¹⁵ Bloomberg New Economy, Bloomberg L.P., New York, NY, USA.
¹⁶ Asia Society Policy Institute, Asia Society, New York, NY, USA.
¹⁷ Daiichi Sankyo, Tokyo, Japan.
¹⁸ Innovent Biologics, Suzhou, China.
¹⁹ Janssen, Johnson and Johnson, New Brunswick, NJ, USA.
²⁰ BeiGene USA, BeiGene, Beijing, China.
²¹ Zai Lab, Shanghai, China.
²² Amgen, Inc, Thousand Oaks, CA, USA.
²³ Genentech, South San Francisco, CA, USA.
²⁴ Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
²⁵ Jiangsu Hengrui Pharmaceuticals, Shanghai, China.
²⁶ Bayer AG, Leverkusen, Germany.
²⁷ Shanghai TuoXin Health Promotion Center, Shanghai, China.
²⁸ CEO Roundtable on Cancer, Morrisville, NC, USA.
²⁹ Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Chinese Thoracic Oncology Group, Guangzhou, China.

^# Contributed equally.

PMID: 35440725
DOI: 10.1038/s41591-022-01775-6

Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition

Bob T Li et al. Nat Med. 2022 Apr.

. 2022 Apr;28(4):620-626.

doi: 10.1038/s41591-022-01775-6.

Authors

Affiliations

¹ Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY, USA. lib1@mskcc.org.
² Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, New York, NY, USA.
³ Princess Margaret Cancer Center, , University of Toronto, Toronto, Ontario, Canada.
⁴ Dana-Farber Brigham Cancer Center, Harvard Medical School, Boston, MA, USA.
⁵ Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁶ Massachusetts General Hospital Cancer Center, Boston, MA, USA.
⁷ Society for Translational Oncology, Durham, NC, USA.
⁸ Oncology Center of Excellence, Food and Drug Administration, Silver Spring, MD, USA.
⁹ Cancer Support Community, Washington, DC, USA.
¹⁰ Foundation Medicine, Inc., Cambridge, MA, USA.
¹¹ Novartis, Basel, Switzerland.
¹² PPD, Inc., Wilmington, NC, USA.
¹³ Resolution Bioscience, Agilent Technologies, Kirkland, WA, USA.
¹⁴ McKinsey Cancer Center, McKinsey & Company.
¹⁵ Bloomberg New Economy, Bloomberg L.P., New York, NY, USA.
¹⁶ Asia Society Policy Institute, Asia Society, New York, NY, USA.
¹⁷ Daiichi Sankyo, Tokyo, Japan.
¹⁸ Innovent Biologics, Suzhou, China.
¹⁹ Janssen, Johnson and Johnson, New Brunswick, NJ, USA.
²⁰ BeiGene USA, BeiGene, Beijing, China.
²¹ Zai Lab, Shanghai, China.
²² Amgen, Inc, Thousand Oaks, CA, USA.
²³ Genentech, South San Francisco, CA, USA.
²⁴ Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
²⁵ Jiangsu Hengrui Pharmaceuticals, Shanghai, China.
²⁶ Bayer AG, Leverkusen, Germany.
²⁷ Shanghai TuoXin Health Promotion Center, Shanghai, China.
²⁸ CEO Roundtable on Cancer, Morrisville, NC, USA.
²⁹ Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Chinese Thoracic Oncology Group, Guangzhou, China.

^# Contributed equally.

PMID: 35440725
DOI: 10.1038/s41591-022-01775-6

No abstract available

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References

1. Flaherty, K. T. et al. Cancer Discov. 11, 1881–1885 (2021). - DOI - PubMed - PMC
1. Murthy, V. H., Krumholz, H. M. & Gross, C. P. JAMA 291, 2720–2726 (2004). - DOI - PubMed
1. Unger, J. M., Vaidya, R., Hershman, D. L., Minasian, L. M. & Fleury, M. E. J. Natl. Cancer Inst. 111, 245–255 (2019). - DOI - PubMed - PMC
1. Lee, S. J. C. et al. J. Clin. Oncol. 37, 1993–1996 (2019). - DOI - PubMed - PMC
1. Getz, K. A. Clin. Ther. 39, 2203–2213 (2017). - DOI - PubMed

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Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition

Affiliations

Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition

Authors

Affiliations

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical