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Review
. 2023 Jan;43(1):89-106.
doi: 10.1002/jat.4333. Epub 2022 May 5.

Progress on the toxicity of quantum dots to model organism-zebrafish

Changcun Bai  1 , Meng Tang  1
Affiliations
Review

Progress on the toxicity of quantum dots to model organism-zebrafish

Changcun Bai et al. J Appl Toxicol. 2023 Jan.

Abstract

In vivo toxicological studies are currently necessary to analyze the probable dangers of quantum dots (QDs) to the environment and human safety, due to the fast expansion of QDs in a range of applications. Because of its high fecundity, cost-effectiveness, well-defined developmental phases, and optical transparency, zebrafish has long been considered the "gold standard" for biosafety assessment of chemical substances and pollutants. In this review, the advantages of using zebrafish in QD toxicity assessment were explored. Then, the target organ toxicities such as developmental toxicity, immunotoxicity, cardiovascular toxicity, neurotoxicity, and hepatotoxicity were summarized. The hazardous effects of different QDs, including cadmium-containing QDs like CdTe, CdSe, and CdSe/ZnS, as well as cadmium-free QDs like graphene QDs (GQDs), graphene oxide QDs (GOQDs), and others, were emphasized and described in detail, as well as the underlying mechanisms of QDs generating these effects. Furthermore, general physicochemical parameters determining QD-induced toxicity in zebrafish were introduced, such as chemical composition and surface coating/modification. The limitations and special concerns of using zebrafish in QD toxicity studies were also mentioned. Finally, we predicted that the utilization of high-throughput screening assays and omics, such as transcriptome sequencing, proteomics, and metabolomics will be popular topic in nanotoxicology.

Keywords: cadmium-containing quantum dots; cadmium-free quantum dots; nanotoxicity; quantum dots; zebrafish model.

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References

REFERENCES

    1. Alivisatos, A. P. (1996). Semiconductor clusters, nanocrystals, and quantum dots. Science, 271(5251), 933-937. https://doi.org/10.1126/science.271.5251.933
    1. Bai, C., & Tang, M. (2019). Toxicological study of metal and metal oxide nanoparticles in zebrafish. Journal of Applied Toxicology, 40(1), 37-63. https://doi.org/10.1002/jat.3910
    1. Bakkers, J. (2011). Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovascular Research, 91(2), 279-288. https://doi.org/10.1093/cvr/cvr098
    1. Bangeppagari, M., Park, S. H., Kundapur, R. R., & Lee, S. J. (2019). Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment. Science of the Total Environment, 673, 810-820. https://doi.org/10.1016/j.scitotenv.2019.04.082
    1. Cassar, S., Adatto, I., Freeman, J. L., Gamse, J. T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R. T., Van Cruchten, S., & Zon, L. I. (2020). Use of zebrafish in drug discovery toxicology. Chemical Research in Toxicology, 33(1), 95-118. https://doi.org/10.1021/acs.chemrestox.9b00335

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