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Observational Study
. 2022 Mar 21;92(S4):e2021417.
doi: 10.23750/abm.v92iS4.12666.

Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio

Pietro Marchese  1 , Chiara Lardone  2 , Alessia Canepele  3 , Samanta Biondi  4 , Costantino Roggi  5 , Francesco Massart  6 , Alice Bonuccelli  7 , Diego Peroni  8 , Alice Giotta Lucifero  9 , Sabino Luzzi  10 , Thomas Foiadelli  11 , Alessandro Orsini  12
Affiliations
Observational Study

Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio

Pietro Marchese et al. Acta Biomed. .

Abstract

Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury), which, in addition to neuro-protective effects, can mediate secondary neurological injury. The neutrophil-to-lymphocyte ratio (NLR), as a circulating inflammatory marker, has been related to outcomes in adult patients with non-neurologic diseases (such as gut tumours) or neurologic diseases (such as stroke or brain tumours), and to the prognosis of traumatic brain injury in adolescents and adults. However, the potential role of NLR in predicting outcomes in paediatric head trauma is not clearly defined. The aim of this retrospective observational study is to evaluate the association between clinical features predictive of intracranial and extracranial lesions in TBI and NLR and to establish whether an elevation of NLR is indirectly associated with adverse outcomes in pediatric patients with TBI. We analysed a sample of 219 pediatric patients, between 2-18 years old, after a TBI, and evaluated if differences in NLR were associated with neurological signs or positive CT in pediatric patients. We then compared the NLR values ​​between healthy subjects and patients with TBI.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.. Median and Interquartile range of NLRn and NLR% in patient with and without confirmed internal injuries by CT and comparison between the former and healthy subjects
See this image and copyright information in PMC

References

    1. Da Dalt L, Parri N, Amigoni A, et al. Italian guidelines on the assessment and management of pediatric head injury in the emergency department. Ital J Pediatr. 2018;44(1):7. - PMC - PubMed
    1. Elsawaf Y, Anetsberger S, Luzzi S, Elbabaa SK. Early Decompressive Craniectomy as Management for Severe Traumatic Brain Injury in the Pediatric Population: A Comprehensive Literature Review. World Neurosurg. 2020;138:9–18. - PubMed
    1. Savioli G, Ceresa IF, Macedonio S, Gerosa S, Belliato M, Iotti GA, et al. Trauma Coagulopathy and Its Outcomes. Medicina (Kaunas) 2020;56(S4) - PMC - PubMed
    1. Belisle S, Lim R, Hochstadter E, Sangha G. Approach to Pediatric Traumatic Brain Injury in the Emergency Department. Curr Pediatr Rev. 2018;14(1):4–8. - PubMed
    1. Choe M, Barlow KM. Pediatric Traumatic Brain Injury and Concussion. Continuum (Minneap Minn) 2018;24((1, Child Neurology)):300–11. - PubMed

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