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Review
. 2022 Mar 21;92(S4):e2021414.
doi: 10.23750/abm.v92iS4.12663.

Therapeutic aspects of Sydenham's Chorea: an update

Greta Depietri  1 , Niccolo Carli  2 , Attilio Sica  3 , Domenico Oliviero  4 , Giorgio Costagliola  5 , Pasquale Striano  6 , Alice Bonuccelli  7 , Flavia Frisone  8 , Diego Peroni  9 , Rita Consolini  10 , Thomas Foiadelli  11 , Alessandro Orsini  12
Affiliations
Review

Therapeutic aspects of Sydenham's Chorea: an update

Greta Depietri et al. Acta Biomed. .

Abstract

Sydenham's Chorea (SC) is a hyperkinetic movement disorder associated with neuropsychiatric manifestations. It is believed to be caused by the autoimmune response following a group A beta-hemolytic streptococcal (GABHS) pharyngitis, and it is one of the major diagnostic criteria for Acute Rheumatic Fever (ARF) diagnosis. Despite having been known and studied for centuries, there are still no standardized therapies or official guidelines for SC treatment, so that it is necessarily left to physicians' clinical experience. Antibiotic treatment, symptomatic therapies, and immunomodulatory treatment are the three pillars upon which SC patients' management is currently based, but they still lack a solid scientific basis. The aim of this writing is precisely to review the state of the art of SC's treatment, with an overview of the advances made in the last 5 years. However, since the therapeutic uncertainties are a mere reflection of the severe gap of knowledge that concerns SC's pathogenesis and manifestations, the importance of high-quality research studies based on homogenized methodologies, instruments, and measured outcomes will also be stressed.

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Figures

Figure 1.
Figure 1.
Treatment Algorithm for Sydenham’s Chorea
See this image and copyright information in PMC

References

    1. Marques-Dias MJ, Mercadante MT, Tucker D. Lom-broso P. Sydenham’s chorea. Psychiatr Clin North Am. 1997;20(4):809–820. - PubMed
    1. Cardoso F., Sydenham’s Chorea. Curr Treat Options Neurol. 2008;10(3):230–235. - PubMed
    1. Punukollu M, Mushet N, Linney M, Hennessy C, Morton M. Neuropsychiatric manifestations of Sydenham’s chorea: a systematic review. Dev Med Child Neurol. 2016;58(1):16–28. - PubMed
    1. Eshel G, Lahat E, Azizi E, Gross B, Aladjem M. Chorea as a manifestation of rheumatic fever--a 30-year survey (19601990) Eur J Pediatr. 1993;152(8):645–646. - PubMed
    1. Baizabal-Carvallo JF, Jankovic J. Movement disorders in autoimmune diseases. Mov Disord. 2012;27(8):935–946. - PubMed