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Meta-Analysis
. 2022 Mar 21;92(S4):e2021420.
doi: 10.23750/abm.v92iS4.12669.

Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II)

Alice Giotta Lucifero  1 , Matias Baldoncini  2 , Ilaria Brambilla  3 , Monica Rutigliano  4 , Gabriele Savioli  5 , Renato Galzio  6 , Alvaro Campero  7 , Michael T Lawton  8 , Sabino Luzzi  9
Affiliations
Meta-Analysis

Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II)

Alice Giotta Lucifero et al. Acta Biomed. .

Abstract

Introduction The interleukin-6 (IL-6), a proinflammatory cytokine, supports the adaptive immune response and regulates inflammatory processes. The -174 G>C and -572 G>C promoter polymorphisms of the IL-6 gene take part in the pathogenesis of intracranial aneurysms (IAs) and influence the clinical presentation of subarachnoid hemorrhage. This meta-analysis purposes to evaluate whether and which IL-6 allelic variations are related to a risk of IAs formation. Methods A PRISMA-based literature search was performed on the PubMed/Medline and Web of Science databases. The keywords used were "interleukin-6," "IL-6," "polymorphism," "interleukin-6 genotype," combined with "intracranial aneurysms" and "subarachnoid hemorrhage." Only human case-control studies, with a study (IAs) and a control group, written in English, and published in the last 15 years were selected. A meta-analysis was performed, estimating odds ratios and 95% confidence intervals in fixed- or random-effects models, as applicable. Statistical analysis was conducted with RevMan 5.0 software. Results 9 studies were eligible. No associations were found between -174 G>C polymorphisms and IAs susceptibility. Notable results were reported by the analysis of -572G>C polymorphisms. -572GG/GC/CC genotypes were strongly related to IAs occurrence with a statistical significance of p=0.03, p=0.0009, and p=0.00001, respectively. Conclusion A higher incidence of -572G>C promoter polymorphisms were demonstrated in the IAs group, highlighting the pivotal role of inflammatory genes in the natural history of brain aneurysms. Additional studies are required considering the racial heterogenicity and the need to widen the population sample.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.. PRISMA flow diagram on the meta-analysis selection process
Figure 2.
Figure 2.. Forest plot for -174GG polymorphism
Figure 3.
Figure 3.. Forest plot for -174GC polymorphism
Figure 4.
Figure 4.. Forest plot for -174CC polymorphism
Figure 5.
Figure 5.. Forest plot for -572GG polymorphism. (A) Fixed and (B) random model.
Figure 6.
Figure 6.. Forest plot for -572GC polymorphism. (A) Fixed and (B) random model..
Figure 7.
Figure 7.. Forest plot for -572CC polymorphism. (A) Fixed and (B) random model
Figure 8.
Figure 8.. Funnel plot for -174G>C polymorphisms
Figure 9.
Figure 9.. Funnel plot for -572G>C polymorphisms
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