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Meta-Analysis
. 2023 Jan;42(1):7-15.
doi: 10.1002/jum.15988. Epub 2022 Apr 20.

Is Hysterosalpingo-Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta-Analysis

Enze Qu  1 , Man Zhang  1 , Jinxiu Ju  1 , Ying Chen  1 , Xin Lin  1 , Xinling Zhang  1
Affiliations
Meta-Analysis

Is Hysterosalpingo-Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta-Analysis

Enze Qu et al. J Ultrasound Med. 2023 Jan.

Abstract

This study aimed to evaluate the diagnostic value of HyCoSy using sulfur hexafluoride microbubbles for fallopian tubal patency assessment in infertile females. Twenty-four studies, including 1358 females with 2661 detected fallopian tubes published from January 2003 to May 2019, were identified. The pooled sensitivity was 93% (95% CI: 90-95%), while the specificity was 90% (95% CI: 87-92%). The area under the receiver-operating characteristic curve was 0.96 (95% CI: 94-98%). The specificity of the four-dimensional HyCoSy subgroup was higher than the 2D/3D subgroup; an increased dose of contrast agent did not affect the specificity, with only a slightly reduced sensitivity.

Keywords: SonoVue; fallopian tube patency tests; hysterosalpingography; infertility; ultrasonography.

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