Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Apr 22;8(16):eabq2807.
doi: 10.1126/sciadv.abq2807. Epub 2022 Apr 20.

Toward more streamlined testing in pediatric oncology

Michael F Walsh  1
Affiliations
Review

Toward more streamlined testing in pediatric oncology

Michael F Walsh. Sci Adv. .

Abstract

Gene sequencing of blood plasma simultaneously detects cancer and infectious disease in pediatric leukemia patients.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.. Tandem genome sequencing detects residual leukemia and viral pathogens in cfDNA.
A custom blood test showing genetic disease variants and infection, the two factors implicated in negative prognosis, could reduce the number of invasive bone marrow biopsies and aspirations pediatric leukemia patients may be required to undergo. ctDNA, circulating tumor DNA. cfDNA, cell-free DNA. Credit: Ashley Mastin/Science Advances.
See this image and copyright information in PMC

References

    1. Pui C. H., Precision medicine in acute lymphoblastic leukemia. Front. Med. 14, 689–700 (2020). - PMC - PubMed
    1. McDermott U., Downing J. R., Stratton M. R., Genomics and the continuum of cancer care. N. Engl. J. Med. 364, 340–350 (2011). - PubMed
    1. Relman D. A., Microbial genomics and infectious diseases. N. Engl. J. Med. 365, 347–357 (2011). - PMC - PubMed
    1. Fiala E. M., Jayakumaran G., Mauguen A., Kennedy J. A., Bouvier N., Kemel Y., Fleischut M. H., Maio A., Salo-Mullen E. E., Sheehan M., Arnold A. G., Latham A., Carlo M. I., Cadoo K., Murkherjee S., Slotkin E. K., Trippett T., Bender J. G., Meyers P. A., Wexler L., Dela Cruz F. S., Cheung N.-K., Basu E., Kentsis A., Ortiz M., Francis J. H., Dunkel I. J., Khakoo Y., Gilheeney S., Sait S. F., Forlenza C. J., Sulis M., Karajannis M., Modak S., Gerstle J. T., Heaton T. E., Roberts S., Yang C., Jairam S., Vijai J., Topka S., Friedman D. N., Stadler Z. K., Robson M., Berger M. F., Schultz N., Ladanyi M., O’Reilly R. J., Abramson D. H., Ceyhan-Birsoy O., Zhang L., Mandelker D., Shukla N. N., Kung A. L., Offit K., Zehir A., Walsh M. F., Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors. Nat. Cancer 2, 357–365 (2021). - PMC - PubMed
    1. Bouffet E., Larouche V., Campbell B. B., Merico D., de Borja R., Aronson M., Durno C., Krueger J., Cabric V., Ramaswamy V., Zhukova N., Mason G., Farah R., Afzal S., Yalon M., Rechavi G., Magimairajan V., Walsh M. F., Constantini S., Dvir R., Elhasid R., Reddy A., Osborn M., Sullivan M., Hansford J., Dodgshun A., Klauber-Demore N., Peterson L., Patel S., Lindhorst S., Atkinson J., Cohen Z., Laframboise R., Dirks P., Taylor M., Malkin D., Albrecht S., Dudley R. W. R., Jabado N., Hawkins C. E., Shlien A., Tabori U., Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency. J. Clin. Oncol. 34, 2206–2211 (2016). - PubMed