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Multicenter Study
. 2022 Oct 25;86(11):1769-1776.
doi: 10.1253/circj.CJ-21-1062. Epub 2022 Oct 15.

Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2

Yasuaki Takeji  1 , Tomohiko Taniguchi  2 , Takeshi Morimoto  3 , Shinichi Shirai  4 , Takeshi Kitai  2   5 , Hiroyuki Tabata  4 , Kazuki Kitano  4 , Nobuhisa Ono  6 , Ryosuke Murai  2 , Kohei Osakada  7 , Koichiro Murata  8 , Masanao Nakai  9 , Hiroshi Tsuneyoshi  10 , Tomohisa Tada  11 , Masashi Amano  5 , Hiroki Shiomi  1 , Hirotoshi Watanabe  1 , Yusuke Yoshikawa  1 , Ko Yamamoto  1 , Mamoru Toyofuku  12 , Shojiro Tatsushima  12 , Norino Kanamori  13 , Makoto Miyake  14 , Hiroyuki Nakayama  15 , Kazuya Nagao  16 , Masayasu Izuhara  17 , Kenji Nakatsuma  18 , Moriaki Inoko  19 , Takanari Fujita  12 , Masahiro Kimura  20 , Mitsuru Ishii  21 , Shunsuke Usami  22 , Kenichiro Sawada  5 , Fumiko Nakazeki  23 , Marie Okabayashi  23 , Manabu Shirotani  24 , Yasutaka Inuzuka  25 , Tatsuhiko Komiya  26 , Kenji Minatoya  27 , Takeshi Kimura  1 ; CURRENT AS Registry-2 Investigators
Affiliations
Free article
Multicenter Study

Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2

Yasuaki Takeji et al. Circ J. .
Free article

Erratum in

  • CORRIGENDUM: Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2.
    Takeji Y, Taniguchi T, Morimoto T, Shirai S, Kitai T, Tabata H, Kitano K, Ono N, Murai R, Osakada K, Murata K, Nakai M, Tsuneyoshi H, Tada T, Amano M, Shiomi H, Watanabe H, Yoshikawa Y, Yamamoto K, Toyofuku M, Tatsushima S, Kanamori N, Miyake M, Nakayama H, Nagao K, Izuhara M, Nakatsuma K, Inoko M, Fujita T, Kimura M, Ishii M, Usami S, Sawada K, Nakazeki F, Okabayashi M, Shirotani M, Inuzuka Y, Komiya T, Minatoya K, Kimura T; CURRENT AS Registry-2 Investigators. Takeji Y, et al. Circ J. 2023;87(8):1146-1149. doi: 10.1253/circj.CJ-66-0215. Circ J. 2023. PMID: 37495511 No abstract available.

Abstract

Background: There is scarce data evaluating the current practice pattern and clinical outcomes for patients with severe aortic stenosis (AS), including both those who underwent surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) and those who were managed conservatively in the TAVI era.

Methods and results: The Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis (CURRENT AS) Registry-2 is a prospective, physician-initiated, multicenter registry enrolling consecutive patients who were diagnosed with severe AS between April 2018 and December 2020 among 21 centers in Japan. The rationale for the prospective enrollment was to standardize the assessment of symptomatic status, echocardiographic evaluation, and other recommended diagnostic examinations such as computed tomography and measurement of B-type natriuretic peptide. Moreover, the schedule of clinical and echocardiographic follow up was prospectively defined and strongly recommended for patients who were managed conservatively. The entire study population consisted of 3,394 patients (mean age: 81.6 years and women: 60%). Etiology of AS was degenerative in 90% of patients. AS-related symptoms were present in 60% of patients; these were most often heart failure symptoms. The prevalence of high- and low-gradient AS was 58% and 42%, respectively, with classical and paradoxical low-flow low-gradient AS in 4.6% and 6.7%, respectively.

Conclusions: The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.

Keywords: Aortic stenosis; Surgical aortic valve replacement; Transcatheter aortic valve implantation.

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