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Review
. 2022 Mar 31:77:103415.
doi: 10.1016/j.amsu.2022.103415. eCollection 2022 May.

Molecular Patho-mechanisms of cervical cancer (MMP1)

Iwan Kurnia  1 , Syahrul Rauf  1 , Mochammad Hatta  2 , Sharvianty Arifuddin  1 , Yudi Maulana Hidayat  3 , Rosdiana Natzir  4 , Cahyo Kaelan  5 , Agussalim Bukhari  6 , Nugraha Utama Pelupessy  1 , Ilham Jaya Patelonggi  7
Affiliations
Review

Molecular Patho-mechanisms of cervical cancer (MMP1)

Iwan Kurnia et al. Ann Med Surg (Lond). .

Abstract

Cervical cancer mostly caused by Human Papilloma Virus. Staging and therapy have been extensively studied, and highly correlated with the cellular development of oncogenesis. Mutation was caused by E6 and E7 oncoprotein, also inactivation of 2 tumor suppressor factors (pRB and p53). P53 also regulated MMP1, which dysregulation of MMP transcription would promote tumor metastasis, because of its role in extracellular matrix degradation in tumor invasion. Clinical staging of Cervical Cancer was based on Federation International of Gynaecology and Obstetrics (FIGO) classification from 2018. Management was divided into Surgery, Radiotherapy, and Chemotherapy.

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Figures

Pic 1
Pic 1
HPV Mechanism of Action in deactivating Tumor Suppressor Gene [2].
Pic 2
Pic 2
Carcinogenesis in persistent HPV [3]→16.
Pic 3
Pic 3
MMP1 role in Cancer Progressivity [4].
Pic 4
Pic 4
MMP1 role in tumor development and progressiveness [5].
Image 1
See this image and copyright information in PMC

References

    1. Nuranna L., Aziz M.F., Cornain S., Purwoto G., Purbadi S., Budiningsih S., et al. Cervical cancer prevention program in Jakarta, Indonesia: see and Treat model in developing country. J. Gynecol. Oncol. 2012;23(3):147–152. - PMC - PubMed
    1. Suh Y., Amelio I., Guerrero Urbano T., Tavassoli M. Clinical update on cancer: molecular oncology of head and neck cancer. Cell Death Dis. 2014;5(1) doi: 10.1038/cddis.2013.548. [Internet] e1018-12. Available from: - DOI - PMC - PubMed
    1. Ohtsubo M., Theodoras A.M., Schumacher J., Roberts J.M., Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell Biol. 1995;15(5):2612–2624. - PMC - PubMed
    1. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer. 2002;2(3):161–174. - PubMed
    1. Barillari G., Monini P., Sgadari C., Ensoli B. The impact of human papilloma viruses, matrix metallo-proteinases and HIV protease inhibitors on the onset and progression of uterine cervix epithelial tumors: a review of preclinical and clinical studies. Int. J. Mol. Sci. 2018;19(5) - PMC - PubMed