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Comment
. 2022 Jun;600(11):2541-2542.
doi: 10.1113/JP283011. Epub 2022 Apr 30.

LEtS set the tone

Vikram Joshi  1 , Arthur Beyder  1   2
Affiliations
Comment

LEtS set the tone

Vikram Joshi et al. J Physiol. 2022 Jun.
No abstract available

Keywords: calcium; gastrointestinal; interstitial cells of Cajal; lower esophageal sphincter; motility.

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Conflict of interest statement

Author Conflict: No competing interests declared

Comment on

References

    1. Drumm BT, Hannigan KI, Lee JY, Rembetski BE, Baker SA, Koh SD, Cobine CA & Sanders KM. (2022). Ca(2+) signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower esophageal sphincters. J Physiol. - PMC - PubMed
    1. Goyal RK & Chaudhury A. (2010). Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut. Am J Physiol Gastrointest Liver Physiol 298, G10–13. - PMC - PubMed
    1. Groneberg D, Zizer E, Lies B, Seidler B, Saur D, Wagner M & Friebe A. (2015). Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter. J Physiol 593, 403–414. - PMC - PubMed
    1. Jiang Y, Bhargava V & Mittal RK. (2009). Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol 297, G397–405. - PMC - PubMed
    1. Mittal R & Vaezi MF. (2020). Esophageal Motility Disorders and Gastroesophageal Reflux Disease. N Engl J Med 383, 1961–1972. - PubMed

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